3 documents found, page 1 of 1
Photonic modulation of epidermal growth factor receptor halts receptor activati...
Botelho, Cláudia M.; Gonçalves, O.; Marques, R.; Thiagarajan, V.; Vorum, H.; Gomes, Andreia C; Petersen-Neves, T.Epidermal Growth Factor Receptor (EGFR) plays a key role in regulating cell survival, proliferation and migration, and its overexpression and activation has been correlated with cancer progression. Cancer therapies targeting EGFR have been applied in the clinic with some success. We show, by confocal microscopy analysis, that illumination of adenocarcinomic human alveolar basal epithelial cells (Human A549 EGFR...
Synthetic Protein Biotechnology approaches for the creation of antimicrobial bi...
Costa, André Manuel Abreu; Machado, Raul; Ribeiro, Artur J.; Collins, Tony; Thiagarajan, V.; Neves-Petersen, M.T.; Rodríguez-Cabello, J.C.[Excerpt] The spread of antimicrobials resistant microorganisms has triggered the search for new ways to treat infections. In the present work we explored the ABP-CM4 peptide properties from Bombyx mori for the creation of biopolymers with broad antimicrobial activity. An antimicrobial recombinant protein-based polymer (rPBP) was designed by cloning the DNA sequence coding for ABP-CM4 in frame with the N-termin...
A thermostable salmonella phage endolysin, Lys68, with broad bactericidal prope...
Oliveira, Hugo; Thiagarajan, V.; Walmagh, Maarten; Sillankorva, Sanna; Lavigne, Rob; Petersen, T. Neves; Kluskens, Leon; Azeredo, JoanaResistance rates are increasing among several problematic Gram-negative pathogens, a fact that has encouraged the development of new antimicrobial agents. This paper characterizes a Salmonella phage endolysin (Lys68) and demonstrates its potential antimicrobial effectiveness when combined with organic acids towards Gram-negative pathogens. Biochemical characterization reveals that Lys68 is more active at pH 7.0...