5 documents found, page 1 of 1
Red blood cell proteomic profiling in mild and severe obstructive sleep apnea p...
Valentim-Coelho, Cristina; Saraiva, Joana; Osorio, Hugo; Antunes, Marília; Vaz, Fátima; Neves, Sofia; Pinto, Paula; Bárbara, Cristina; Penque, DeborahFunding Information: Project partially supported by Harvard Medical School \u2013 Portugal Program ( HMSPICJ/0022/2011 ), Instituto Nacional de Sa\u00FAde Dr. Ricardo Jorge \u2013 INSA, Centro de Toxicogen\u00F3mica e Sa\u00FAde Humana \u2013 ToxOmics, Rede Nacional de Espectrometria de Massa \u2013 RNEM, FCT /Poly-Annual Funding Program and FEDER /Sa\u00FAde XXI Program, Portugal. Cristina Coelho (SFRH/BD/1335...
Extracellular vesicles from pancreatic cancer stem cells lead an intratumor com...
Ruivo, Carolina F.; Bastos, Nuno; Adem, Barbara; Batista, Ines; Duraes, Cecilia; Melo, Carlos A.; Castaldo, Stephanie A.; Campos‐Laborie, FranciscoObjective: Intratumor heterogeneity drives cancer progression and therapy resistance. However, it has yet to be determined whether and how subpopulations of cancer cells interact and how this interaction affects the tumour. Design: We have studied the spontaneous flow of extracellular vesicles (EVs) between subpopulations of cancer cells: cancer stem cells (CSC) and non-stem cancer cells (NSCC). To determine th...
Chicken feather keratin peptides for the control of keratinocyte migration
Botelho, C. M.; Santos, Pedro Miguel Ferreira; Toubarro, Duarte; Dinis, Hugo; Osorio, Hugo; Costa-Barbosa, Augusto; Sampaio, Paula; Simoes, NelsonFeatured Application The work described in this paper has significant potential for medical applications. As an example, these peptides can be incorporated into wound dressings to treat chronic wounds, increasing their re-epithelization, or to treat other skin diseases, such as psoriasis. FAO estimates that in 2030 the poultry meat production could reach 120 million tons, which is a challenge in terms of waste ...
Influence of dietary supplementation with an amino acid mixture on inflammatory...
Prates, José A.M; Freire, João; Almeida, André; Martins, Cátia Falcão; Ribeiro, David M.; Osorio, Hugo; Pinho, Mário; Lopes, Paula AlexandraIn order to investigate the effect of a dietary amino acid mixture supplementation in lipopolysaccharide (LPS)-challenged weaned piglets, twenty-seven 28-day-old (8.2 ± 1.0 kg) newly weaned piglets were randomly allocated to one of three experimental treatments for five weeks. Diet 1: a CTRL treatment. Diet 2: an LPS treatment, where piglets were intraperitoneally administered LPS (25 μg/kg) on day 7. Diet 3: a...
Impact of thermal treatment and hydrolysis by Alcalase and Cynara cardunculus e...
Voss, Glenise B.; Osorio, Hugo; Valente, Luís M. P.; Pintado, Manuela E.Enzymatic hydrolysis of dried okara (autoclaved and non-autoclaved) with Alcalase (AL) and Cynara cardunculus extract (CY) was studied, assessing the impact of heat treatment and hydrolysis on potential antioxidant and antihypertensive activities of final hydrolysates. This study showed that the thermal treatment (sterilization at 121 °C, 1 atm and 15 min) facilitated the enzymatic access to substrate and incre...