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Echocardiographic measurements in a preclinical model of chronic chagasic cardi...
Carvalho, Eduardo Butturini de; Ramos, Isalira Peroba Rezende; Nascimento, Alvaro Fernando da Silva do; Brasil, Guilherme Visconde; Mello, Debora BastosBackground: The failure to translate preclinical results to the clinical setting is the rule, not the exception. One reason that is frequently overlooked is whether the animal model reproduces distinctive features of human disease. Another is the reproducibility of the method used to measure treatment effects in preclinical studies. Left ventricular (LV) function improvement is the most common endpoint in precl...
Date: 2020
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Origin: Oasisbr