3 documents found, page 1 of 1
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Diso...
Mullins, Niamh; Kang, JooEun; Campos, Adrian I; Coleman, Jonathan R I; Edwards, Alexis C; Galfalvy, Hanga; Levey, Daniel F; Lori, AdrianaBackground: Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods: We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) c...
Analysis of shared heritability in common disorders of the brain
Anttila, Verneri; Bulik-Sullivan, Brendan; Finucane, Hilary K.; Walters, Raymond K.; Bras, Jose; Duncan, Laramie; Escott-Price, ValentinaDisorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common varian...
Long repeat tracts at SCA8 in major psychosis
Vincent, John B.; Yuan, Qiu-Ping; Schalling, Martin; Adolfsson, R; Azevedo, M. Helena; Macedo, António; Bauer, Amy; DallaTorre, CamilleExpansion at a recently identified unstable trinucleotide repeat on chromosome 13q21 has been reported as the molecular cause for spinocerebellar ataxia type 8 (SCA8). The trinucleotide repeat, which consists of a [CTA]n repeat and adjacent [CTG]n repeat, was reported to have a pathogenic range of 107-127 CTG repeats (or 110-130 combined CTA and CTG repeats) in a large ataxia kindred. This repeat region was als...