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I329L: A Dual Action Viral Antagonist of TLR Activation Encoded by the African ...
Correia, Silvia; Moura, Pedro Luís; Ventura, Sónia; Leitão, Alexandre; Parkhouse, Robert Michael EvansABSTRACT - The African Swine Fever Virus (ASFV) is an economically important, large DNA virus which causes a highly contagious and frequently fatal disease in domestic pigs. Due to the acute nature of the infection and the complexity of the protective porcine anti-ASFV response, there is no accepted vaccine in use. As resistance to ASFV is known to correlate with a robust IFN response, the virus is predicted to...
Utilização de teste sorológico ELISA para a detecção de bovinos naturalmente in...
Paulan, Silvana de Cássia [UNESP]; Gonzáles, Rutilia Marisela Hernándes; Peralta, Laura Adalid; Vicentini-Oliveira, Josy Campanhã [UNESP]Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:28:48Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:32:24Z : No. of bitstreams: 1 2-s2.0-84879252473.pdf: 385255 bytes, checksum: d3d85c11660d4998f53256da7f30583c (MD5); Made available in DSpace on 2014-05-27T11:28:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-04-01; Conselho Nacional de Desenvolviment...
Human Cytomegalovirus Gene UL76 Induces IL-8 Expression through Activation of t...
Costa, Helena; Nascimento, Rute; Sinclair, John; Parkhouse, Robert Michael EvansHuman cytomegalovirus (HCMV), a β-herpesvirus, has evolved many strategies to subvert both innate and adaptive host immunity in order to ensure its survival and propagation within the host. Induction of IL-8 is particularly important during HCMV infection as neutrophils, primarily attracted by IL-8, play a key role in virus dissemination. Moreover, IL-8 has a positive effect in the replication of HCMV. This wor...
Neoplastic Transformation of T Lymphocytes through Transgenic Expression of a V...
Almeida, Sílvia Cristina Paiva; de Oliveira, Vivian Leite; Ventura, Sónia; Bofill, Margarita; Parkhouse, Robert Michael EvansVirus host evasion genes are ready-made tools for gene manipulation and therapy. In this work we have assessed the impact in vivo of the evasion gene A238L of the African Swine Fever Virus, a gene which inhibits transcription mediated by both NF-κB and NFAT. The A238L gene has been selectively expressed in mouse T lymphocytes using tissue specific promoter, enhancer and locus control region sequences for CD2. T...