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Association between cognitive reserve proxies and frailty phenotype: data from ...
Lorenzo-López, L; Cibeira, N; Hemadeh, A; López-López, R; Lema-Arranz, C; Maseda, A; Fernández-Bertólez, N; Costa, S; Pásaro, E; Valdiglesias, VA potential protective role of cognitive reserve proxies against frailty has been suggested in older adults. We explored the cross-sectional association between cognitive reserve indicators and frailty phenotype. Data were obtained from the UK Biobank. We included 31,975 dementia-free participants aged ≥ 60 years (50.7% females, 2.2% frail) who completed a web-based cognitive assessment (fluid intelligence, wor...
Toxoplasma gondii IgG Serointensity Is Positively Associated With Frailty
Mohyuddin, H; Laffon, B; Teixeira, JP; Costa, S; Teixeira-Gomes, A; Pásaro, E; Constantine, N; Dagdag, A; Ortmeyer, HK; Tizenberg, B; Afram, L; Yen, PYBackground: Persistent inflammation related to aging (inflammaging) is exacerbated by chronic infections and contributes to frailty in older adults. We hypothesized associations between Toxoplasma gondii (T. gondii), a common parasite causing an oligosymptomatic unremitting infection, and frailty, and secondarily between T. gondii and previously reported markers of immune activation in frailty.Methods: We analy...
Toxicological Aspects of Iron Oxide Nanoparticles
Fernández-Bertólez, N; Costa, C; Brandão, F; Teixeira, JP; Pásaro, E; Valdiglesias, V; Laffon, BIron oxide nanoparticles (ION), with unique magnetic properties, have attracted huge scientific attention for a wide variety of uses, mostly in the biomedical field, due to their high biocompatibility, ability to cross biological membranes, appropriate surface architecture and easy conjugation with targeting ligands. Their current applications include diagnostic imaging, cell labelling, site-directed drug deliv...
Relationship between DNA damage measured by the comet-assay and cognitive function
Lorenzo-López, L; Lema-Arranz, C; Fernández-Bertólez, N; Costa, S; Costa, C; Teixeira, JP; Pásaro, E; Valdiglesias, V; Laffon, BRecent studies exploring the relationship between DNA damage measured by the comet assay (single-cell gel electrophoresis) and cognitive function in both animal models and humans are reviewed and summarized. This manuscript provides an overview of studies exploring cognitive dysfunction related to DNA damage due to biological ageing process, cancer treatment, adverse environmental or occupational exposures, and...
Suitability of the In Vitro Cytokinesis-Block Micronucleus Test for Genotoxicit...
Fernández-Bertólez, N; Brandão, F; Costa, C; Pásaro, E; Teixeira, JP; Laffon, B; Valdiglesias, VStandard toxicity tests might not be fully adequate for evaluating nanomaterials since their unique features are also responsible for unexpected interactions. The in vitro cytokinesis-block micronucleus (CBMN) test is recommended for genotoxicity testing, but cytochalasin-B (Cyt-B) may interfere with nanoparticles (NP), leading to inaccurate results. Our objective was to determine whether Cyt-B could interfere ...
Salivary Leucocytes as In Vitro Model to Evaluate Nanoparticle-Induced DNA Damage
Valdiglesias, V; Fernández-Bertólez, N; Lema-Arranz, C; Rodríguez-Fernández, R; Pásaro, E; Reis, AT; Teixeira, JP; Costa, C; Laffon, BMetal oxide nanoparticles (NPs) have a wide variety of applications in many consumer products and biomedical practices. As a result, human exposure to these nanomaterials is highly frequent, becoming an issue of concern to public health. Recently, human salivary leucocytes have been proposed as an adequate non-invasive alternative to peripheral blood leucocytes to evaluate genotoxicity in vitro. The present stu...
Applicability of flow cytometry γH2AX assay in population studies: suitability ...
Laffon, B; Sánchez-Flores, M; Fernández-Bertólez, N; Pásaro, E; Valdiglesias, VPhosphorylation of H2AX histone (γH2AX) represents an early event in the DNA damage response against double-strand breaks (DSB); hence, its measurement provides a surrogate biomarker of DSB. Recently, we reported initial steps in the standardization of γH2AX assay in peripheral blood leukocytes (PBL), addressing the possibility of using cryopreserved samples, and the need of phytohaemagglutinin (PHA) stimulatio...
Low Vitamin D Levels and Frailty Status in Older Adults: A Systematic Review an...
Marcos-Pérez, D; Sánchez-Flores, M; Proietti, S; Bonassi, S; Costa, S; Teixeira, JP; Fernández-Tajes, J; Pásaro, E; Valdiglesias, V; Laffon, BSerum vitamin D deficiency is widespread among older adults and is a potential modifiable risk factor for frailty. Moreover, frailty has been suggested as an intermediate step in the association between low levels of vitamin D and mortality. Hence, we conducted a systematic review of the literature and meta-analysis to test the possible association of low concentrations of serum 25-hydroxyvitamin D (25(OH)D), a...
Genotoxicity of TiO(2) Nanoparticles in Four Different Human Cell Lines (A549, ...
Brandão, F; Fernández-Bertólez, N; Rosário, F; Bessa, MJ; Fraga, S; Pásaro, E; Teixeira, JP; Laffon, B; Valdiglesias, V; Costa, CTitanium dioxide nanoparticles (TiO2 NPs) have a wide variety of applications in many consumer products, including as food additives, increasing the concern about the possible hazards that TiO2 NPs may pose to human health. Although most previous studies have focused on the respiratory system, ingestion must also be considered as an important exposure route. Furthermore, after inhalation or ingestion, TiO2 NPs ...
Association of inflammatory mediators with frailty status in older adults: resu...
Marcos-Pérez, D; Sánchez-Flores, M; Proietti, S; Bonassi, S; Costa, S; Teixeira, JP; Fernández-Tajes, J; Pásaro, E; Laffon, B; Valdiglesias, VFrailty is a geriatric syndrome defined as a status of extreme vulnerability to stressors, leading to a higher risk of negative health-related outcomes. “Inflammaging”, an age-related state of low-grade chronic inflammation, is characterized by an increased concentration of pro-inflammatory cytokines and acute phase proteins. Inflammaging has been postulated as an underlying mechanism of frailty, and several st...