16 documents found, page 1 of 2
Viability assay and DNA double strand break induction in nervous system cells e...
Fernandez-Bertolez, N.; Touzani, A.; Martinez, L.; Méndez, J.; Ramos-Paz, L.; Reis, A.T.; Fraga, S.; Costa, C.; Teixeira, J.P.; Pásaro, E.Cerium dioxide nanoparticles (CeO2 NP) show antioxidant enzyme mimetic properties and free radical scavenging activity. These properties make them a promising material for biomedical applications, but their potential adverse effects are not totally understood yet. Our objective was to assess the biological behaviour of CeO2 NP in human neuronal and glial cells. After carrying out the physical-chemical character...
Utility of salivary leucocytes for biomonitoring of human exposure to nanomater...
Valdiglesias, Vanessa; Fernández-Bertólez, Natália; Touzani, A.; Mendéz, J.; Martinez, L.; Pásaro, E.; Reis, A.T.; Fraga, S.; Teixeira, J.P.; Costa, C.Metal-based nanoparticles (NP) are being increasingly used in a wide variety of applications in consumer products and biomedical practices. As a result, human exposure to these nanomaterials is frequent, becoming a concern to public health. Human salivary leucocytes have been proposed as a proper biological sample for the comet assay, becoming an adequate non-invasive alternative model to evaluate DNA damage. I...
Primary and oxidative DNA damage induced by titanium dioxide nanoparticles in s...
Fernández-Bertólez, Natalia; Rodríguez-Fernández, R.; Lema-Arranz, C.; Pásaro, E.; Reis, Ana Teresa; Teixeira, João Paulo; Costa, Carla; Laffon, BlancaIntroduction Metal oxide nanoparticles (NP) have a wide variety of applications in consumer products and biomedical practices. Recently, salivary leucocytes have been proposed as non-invasive alternative to peripheral blood leucocytes to evaluate the toxic effects of recent exposure to environmental contaminants, particularly those involving inhalatory or oral exposure routes. The present study aimed at evaluat...
Genotoxicity assessment of TiO2 nanoparticles in SH-SY5Y cells: suitability of ...
Fernández-Bertólez, Natalia; Brandão, Fátima; Costa, Carla; Lema-Arranz, C.; Rodríguez-Fernández, R.; Pásaro, E.; Teixeira, J.P.; Laffon, BlancaObjective: to determine whether Cyt-B could interfere with micronuclei (MN) induction by TiO2 NP in human SH-SY5Y cells, as assessed by CBMN test.
Adequacy of the standardised in vitro mammalian cell Micronucleus (MN) test for...
Fernández-Bertólez, Natalia; Rodríguez-Fernández, R.; Lema-Arranz, C.; Pásaro, E.; Brandão, Fátima; Teixeira, João Paulo; Costa, CarlaAbout adequacy of the standardised in vitro mammalian cell Micronucleus (MN) test for nanomaterials genotoxicity testing.
Analysis of cellular damage induced by silica-coated iron oxide nanoparticles o...
Laffon, Blanca; Kiliç, G.; Fernandez Bertólez, N.; Costa, C.; Costa, S.; Teixeira, J.P.; Pásaro, E.; Valdiglesias, V.The objective of this work was to evaluate toxicity induced by silica-coated ION on a human neuronal cell line (SHSY5Y).
In vitro toxicity screening of silica-coated superparamagnetic iron oxide nanop...
Costa, Carla; Brandão, F.; Bessa, M.J.; Costa, S.; Valdiglesias, V.; Kiliç, G.; Fernández-Bertólez, N.; Pásaro, E.; Laffon, B.; Teixeira, João PauloNanotechnology industry is progressing with prospects of substantial benefits to economics and science. Superparamagnetic iron oxide nanoparticles (ION) have been showing excellent magnetic properties, biocompatibility and biodegradability, broadening their potential applications and importance in the biomedical field
Oxidative stress induced by silica-coated iron oxide nanoparticles in SHSY5Y ne...
Kiliç, G.; Costa, C.; Fernández-Bertólez, N.; Costa, S.; Teixeira, Joao Paulo; Pásaro, E.; Laffon, B.; Vdz Park, M.; Valdiglesias, V.Nanotechnology industry is progressing with prospects of substantial benefits to economics and science. Superparamagnetic iron oxide nanoparticles (ION) have been showing excellent magnetic properties, biocompatibility and biodegradability, broadening their potential applications and importance in the biomedical field. Nevertheless, there are increasing concerns as to the potential adverse effects on human heal...
Effects of iron oxide nanoparticles: Cytotoxicity, genotoxicity, developmental ...
Valdiglesias, V.; Kiliç, G.; Costa, C.; Fernández-Bertólez, N; Pásaro, E.; Teixeira, João Paulo; Laffon, B.Iron oxide nanoparticles (ION) with superparamagnetic properties hold great promise for use in various biomedical applications; specific examples include use as contrast agents for magnetic resonance imaging, in targeted drug delivery, and for induced hyperthermia cancer treatments. Increasing potential applications raise concerns over their potential effects on human health. Nevertheless, very little is curren...
Silica-coated iron oxide nanoparticles do not induce DNA double strand breaks o...
Sánchez-Flores, M.; Kiliç, G.; Costa, C.; Fernández-Bertólez, N.; Costa, S.; Teixeira, João Paulo; Pásaro, E.; Valdiglesias, V.; Laffon, B.Since increasing biomedical applications, both diagnostic and therapeutic, of ION are being developed, it is crucial to know how they interact with the cellular material and the possible consequences derived for human health.