2 documents found, page 1 of 1
A Polymeric Nanoparticle Formulation for Targeted mRNA Delivery to Fibroblasts
Rodrigues, Artur Filipe; Rebelo, Catarina; Simões, Susana; Paulo, Cristiana; Pinho, Sónia A.; Francisco, Vitor; Ferreira, LinoMessenger RNA (mRNA)-based therapies offer enhanced control over the production of therapeutic proteins for many diseases. Their clinical implementation warrants formulations capable of delivering them safely and effectively to target sites. Owing to their chemical versatility, polymeric nanoparticles can be designed by combinatorial synthesis of different ionizable, cationic, and aromatic moieties to modulate ...
Metabolic Priming as a Tool in Redox and Mitochondrial Theragnostics
Pinho, Sónia A.; Anjo, Sandra I.; Cunha-Oliveira, TeresaTheragnostics is a promising approach that integrates diagnostics and therapeutics into a single personalized strategy. To conduct effective theragnostic studies, it is essential to create an in vitro environment that accurately reflects the in vivo conditions. In this review, we discuss the importance of redox homeostasis and mitochondrial function in the context of personalized theragnostic approaches. Cells ...