5 documents found, page 1 of 1
Pre-clinical antigenicity studies of an innovative multivalent vaccine for huma...
Cecílio, P; Pérez-Cabezas, B; Fernández, L.; Moreno, J; Carrillo, E; Requena, J; Fichera, E; Reed, S; Coler, R; Kamhawi, S; Oliveira, F; Valenzuela, JThe notion that previous infection by Leishmania spp. in endemic areas leads to robust anti-Leishmania immunity, supports vaccination as a potentially effective approach to prevent disease development. Nevertheless, to date there is no vaccine available for human leishmaniasis. We optimized and assessed in vivo the safety and immunogenicity of an innovative vaccine candidate against human visceral leishmaniasis...
Leishmania infantum exoproducts inhibit human invariant NKT cell expansion and ...
Belo, R; Santarém, N; Pereira, C; Pérez-Cabezas, B; Macedo, F; Leite-de-Moraes, M; Cordeiro-da-Silva, ALeishmania infantum is one of the major parasite species associated with visceral leishmaniasis, a severe form of the disease that can become lethal if untreated. This obligate intracellular parasite has developed diverse strategies to escape the host immune response, such as exoproducts (Exo) carrying a wide range of molecules, including parasite virulence factors, which are potentially implicated in early sta...
Poly-N-acetylglucosamine production by Staphylococcus epidermidis cells increas...
Ferreirinha, P; Pérez-Cabezas, B; Correia, A; Miyazawa, B; França, A; Carvalhais, V; Faustino, A; Cordeiro-da-Silva, A; Teixeira, L; Pier, G; Cerca, NPoly-N-acetylglucosamine (PNAG) is a major component of the Staphylococcus epidermidis biofilm extracellular matrix. However, it is not yet clear how this polysaccharide impacts the host immune response and infection-associated pathology. Faster neutrophil recruitment and bacterial clearance were observed in mice challenged intraperitoneally with S. epidermidis biofilm cells of the PNAG-producing 9142 strain th...
Interleukin-27 early impacts Leishmania infantum infection in mice and correlat...
Pérez-Cabezas, B; Cecílio, P; Robalo, AL; Silvestre, R; Carrillo, E; Moreno, J; San, Martín J; Vasconcellos, R; Cordeiro-da-Silva, AThe complexity of Leishmania-host interactions, one of the main leishmaniasis issues, is yet to be fully understood. We detected elevated IL-27 plasma levels in European patients with active visceral disease caused by Leishmania infantum, which returned to basal levels after successful treatment, suggesting this cytokine as a probable infection mediator. We further addressed this hypothesis recurring to two cla...
Deception and manipulation: The arms of Leishmania, a successful parasite
Cecílio, P; Pérez-Cabezas, B; Santarém, N; Maciel, J; Rodrigues, V; Cordeiro-da-Silva, ALeishmania spp. are intracellular parasitic protozoa responsible for a group of neglected tropical diseases, endemic in 98 countries around the world, called leishmaniasis. These parasites have a complex digenetic life cycle requiring a susceptible vertebrate host and a permissive insect vector, which allow their transmission. The clinical manifestations associated with leishmaniasis depend on complex interacti...