12 documents found, page 1 of 2

Lipid Antigen Presentation by CD1b and CD1d in Lysosomal Storage Disease Patients

The lysosome has a key role in the presentation of lipid antigens by CD1 molecules. While defects in lipid antigen presentation and in invariant Natural Killer T (iNKT) cell response were detected in several mouse models of lysosomal storage diseases (LSD), the impact of lysosomal engorgement in human lipid antigen presentation is poorly characterized. Here, we analyzed the capacity of monocyte-derived dendriti...

Biofilm dormancy enhances antimicrobial tolerance in S. epidermidis

Indwelling medical devices have been increasingly used in modern medicine and have saved millions of lives worldwide. However, they can also be an important source of infections, most commonly caused by coagulase negative-staphylococci, particularly by biofilm forming Staphylococcus epidermidis. A key feature of biofilms is its enhanced tolerance to antibiotics. Several mechanisms have been proposed to contribu...

The pathogenesis of Staphylococcus epidermidis biofilm-associated infections: t...

Poly-N-acetylglucosamine production by Staphylococcus epidermidis cells increas...

Poly-N-acetyl glucosamine (PNAG) is a major component of Staphylococcus epidermidis biofilms extracellular matrix. However, it is not yet clear how this polysaccharide impacts the host immune response and infection-associated pathology. Faster neutrophil recruitment and bacterial clearance was observed in mice challenged intraperitoneally with S. epidermidis biofilm cells of the PNAG-producing 9142 strain than ...

Staphylococcus epidermidis biofilms are resistant to phage infection due to the...

Dormant bacteria within Staphylococcus epidermidis biofilms have low inflammato...

Staphylococcus epidermidis is the most commonly isolated etiological agent of nosocomial infections mainly due to its ability to establish biofilms on indwelling medical devices. Detachment of bacteria from S. epidermidis biofilms and subsequent growth in the planktonic form is a hallmark in the pathogenesis of these infections leading to dissemination. Here we showed that S. epidermidis cells collected from bi...

Medium supplementation with magnesium prevented the induction of dormancy in bi...

Staphylococcus epidermidis is a commensal bacterium that colonizes the skin and mucous membranes, being the most prevalent staphylococcal species found in humans. However, S. epidermidis has the ability of colonize indwelling medical devices establishing biofilms, which makes this bacteria a common cause of bacteraemia particularly in immunocompromised individuals and neonates [1][2]. The presence of high amoun...

A first new look into the interaction of Staphylococcus epidermidis biofilm-rel...

The widespread application of indwelling medical devices in the clinical setting, together with the remarkable ability of the commensal Staphylococcus epidermidis to adhere to these surfaces and form biofilms, has given to this bacterium the recognition of being a leading causative agent of nosocomial infections. Biofilms lifecycle is currently divided into 4 main steps: initial adhesion, accumulation, maturati...

Genomic characterization of the Staphylococcus epidermidis-specific bacteriopha...

Staphylococcus epidermidis is one of the most frequent causative agents of nosocomial infections, predominantly in patients with indwelling medical devices. This microrganism may form biofilms which are microbial structures very tolerant to the host immune defenses and to antibiotherapy. Therefore, studies are needed in order to develop effective methods for biofilm control. Currently, bacteriophages (phages) a...

Staphylococcus epidermidis biofilm lifecycle and its virulence: from plantkonic...