48 documents found, page 1 of 5

Characterization of the striatal extracellular matrix in a mouse model of Parki...

Parkinson’s disease’s etiology is unknown, although evidence suggests the involvement of oxidative modifications of intracellular components in disease pathobiology. Despite the known involvement of the extracellular matrix in physiology and disease, the influence of oxidative stress on the matrix has been neglected. The chemical modifications that might accumulate in matrix components due to their long half-li...

Biocompatibility of Platinum Nanoparticles in Brain ex vivo Models in Physiolog...

Platinum nanoparticles (PtNPs) have unique physico-chemical properties that led to their use in many branches of medicine. Recently, PtNPs gathered growing interest as delivery vectors for drugs, biosensors and as surface coating on chronically implanted biomedical devices for improving electrochemical properties. However, there are contradictory statements about their biocompatibility and impact on target orga...

Data-driven modeling of the cellular pharmacokinetics of degradable chitosan-ba...

Nanoparticle drug delivery vehicles introduce multiple pharmacokinetic processes, with the delivery, accumulation, and stability of the therapeutic molecule influenced by nanoscale pro-cesses. Therefore, considering the complexity of the multiple interactions, the use of data-driven models has critical importance in understanding the interplay between controlling processes. We demonstrate data simulation techni...

Breaking Barriers: Bioinspired Strategies for Targeted Neuronal Delivery to the...

Central nervous system (CNS) disorders encompass a vast spectrum of pathological conditions and represent a growing concern worldwide. Despite the high social and clinical interest in trying to solve these pathologies, there are many challenges to bridge in order to achieve an effective therapy. One of the main obstacles to advancements in this field that has hampered many of the therapeutic strategies proposed...

Exploring Poly(Ethylene Glycol)-Poly(Trimethylene Carbonate) Nanoparticles as C...

Current treatment options for bone-related disorders rely on a systemic administration of therapeutic agents that possess low solubility and intracellular bioavailability, as well as a high pharmacokinetic variability, which in turn lead to major off-target side effects. Hence, there is an unmet need of developing drug delivery systems that can improve the clinical efficacy of such therapeutic agents. Nanoparti...

Titanium dioxide catalytic activity contributes to the process of free radical ...

TiO2 crystallochemical properties have been explored and correlated with the activity of this material in the scavenging of reactive oxygen and nitrogen species (ROS/RNS). It is well known that those highly reactive species are produced by inflammatory cells and neutralized by some oxides, such a titanium dioxide under light. Nevertheless, the mechanism of action of this ceramic material is yet to be fully unde...

Tissue response to neural implants: the use of model systems towards new design...

Tissue response to neural implants: The use of model systems toward new design ...

The development of implantable neuroelectrodes is advancing rapidly as these tools are becoming increasingly ubiquitous in clinical practice, especially for the treatment of traumatic and neurodegenerative disorders. Electrodes have been exploited in a wide number of neural interface devices, such as deep brain stimulation, which is one of the most successful therapies with proven efficacy in the treatment of d...

Delivery of Antisense Oligonucleotides Mediated by a Hydrogel System: In Vitro ...

Biomaterials-based hydrogels are attractive drug-eluting vehicles in the context of RNA therapeutics, such as those utilizing antisense oligonucleotide or RNA interference based drugs, as they can potentially reduce systemic toxicity and enhance in vivo efficacy by increasing in situ concentrations. Here we describe the preparation of antisense oligonucleotide-loaded fibrin hydrogels exploring their application...

Tissue response to neural implants: the use of model systems towards new design...