6 documents found, page 1 of 1
20 years managing malignant pleural mesothelioma: a review of our experience an...
Nunes Caldeira, João; Rodrigues Sousa, Sofia; Figueiredo, Ana Maria; Pêgo, Alice; Barata, FernandoIntroduction: Malignant pleural mesothelioma (MPM) is a rare, but aggressive incurable cancer. A variety of prognostic tools have been developed to guide clinicians and patients in the management of MPM regarding the most appropriate therapy and survival time. Objectives: To evaluate the usefulness of the Brims’ decision tree analysis, the EORTC prognostic score, the CALGB prognostic groups, the modified Glasgo...
Two-year treatment with Pembrolizumab monotherapy in advanced non-small cell lu...
Costa-Martins, Sara; Valente, Salete; Pêgo, Alice; Figueiredo, Ana; Barata, FernandoIntroduction and objectives: Immunotherapy has introduced advances in the treatment of non -small cell lung cancer. However, data from current clinical practice on potential responder groups, optimal duration of treatment and safety issues remain unclear. It is intended to produce a reflection on the population of patients with a favourable response to Pembrolizumab and how they have evolved clinically over tim...
Pharmacogenetics of advanced lung cancer: Predictive value of functional geneti...
Catarata, Maria Joana; Lourenço, Margarida; Martins, Maria Fátima; Frade, João; Pêgo, Alice; Cordeiro, Carlos Robalo; Medeiros, Rui; Ribeiro, RicardoIntroduction AGXT gene codes for the enzyme alanine glyoxylate aminotransferase, which is involved in hepatic peroxisomal metabolism of platinum-based chemotherapeutic agents. The association of genetic variant AGXT rs34116584 on the clinical outcome and response to chemotherapy of patients with non-small cell lung cancer (NSCLC) remains to be established. Our aim was to evaluate the association of functional A...
Germline Genetic Variants of the Renin-Angiotensin System, Hypoxia and Angiogen...
Catarata, Maria Joana; Medeiros, Rui; Oliveira, Maria José; Pêgo, Alice; Frade, João Gonçalo; Martins, Maria de Fátima; Cordeiro, Carlos RobaloThe renin-angiotensin system (RAS) is involved in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. Our aim was to study the association of putatively functional genetic polymorphisms in genes coding for proteins involved in RAS, hypoxia and angiogenesis with non-small cell lung cancer (NSCLC) prognosis.
Germline genetic variants of the renin-angiotensin system, hypoxia and angiogen...
Catarata, Maria Joana; Medeiros, Rui; Oliveira, Maria José; Pêgo, Alice; Frade, João Gonçalo; Martins, Maria Fátima; Robalo Cordeiro, Carlos RobaloIntroduction: The renin–angiotensin system (RAS) is involved in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. Our aim was to study the association of putatively functional genetic polymorphisms in genes coding for proteins involved in RAS, hypoxia and angiogenesis with non-small cell lung cancer (NSCLC) prognosis. Methods: Geno...
Hemangioendotelioma epitelióide da pleura - Uma apresentaç ão rara a propósito ...
André, Sónia; Valente, Carla; Paiva, Benedita; Pêgo, Alice; Carvalho, L.; Luís, A. SegorbeO hemangioendotelioma epitelióide (HEE) é um tumor de origem vascular, de grau intermédio de malignidade, cuja apresentação primária na pleura é rara. Pelo reduzido número de casos descritos na literatura, os autores apresentam o caso de uma doente de 65 anos, que recorreu ao serviço de urgência por toracalgia à direita, com sete meses de evolução, na sequência de um traumatismo torácico. Radiologicamente apres...