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Early manifestation of myocardial involvement in systemic sclerosis
Alves, Patricia Marques; Baptista, Rui; Canha, Catarina; Franco, Fátima; Santos, Lélita Conceição; Pêgo, MarianoIntroduction: Systemic sclerosis (SSc) is a systemic autoimmune disease involving multiple organs. We present a rare case of SSc in which clinical manifestations of cardiac fibrosis occurred early in the disease course. Case report: We report the case of a 40-year-old Caucasian man, previously diagnosed with SSc, who presented with decompensated heart failure. Transthoracic echocardiography was remarkable for s...
Early, real-world experience with direct oral anticoagulants in the treatment o...
Santos, Sónia Martins; Cunha, Susana; Baptista, Rui; Monteiro, Sílvia; Monteiro, Pedro; Gonçalves, Francisco; Pêgo, MarianoIntroduction: Intermediate-high risk pulmonary embolism (IHR-PE) has a poor prognosis, but is under-represented in trials of direct oral anticoagulants (DOACs) in venous thromboembolic disease (VTE). We aimed to assess whether the administration of DOACs was equivalent to the conventional (CONV) treatment of low-molecular weight heparin bridged with warfarin for treating IHR-PE. Methods: We conducted a retrospe...
Exercise echocardiography for the assessment of pulmonary hypertension in syste...
Baptista, Rui; Serra, Sara; Martins, Rui; Teixeira, Rogério; Castro, Graça; Salvador, Maria João; Silva, José António Pereira da; Santos, LélitaBackground: Pulmonary arterial hypertension (PAH) complicates the course of systemic sclerosis (SSc) and is associated with poor prognosis. The elevation of systolic pulmonary arterial pressure (sPAP) during exercise in patients with SSc with normal resting haemodynamics may anticipate the development of PAH. Exercise echocardiography (ExEcho) has been proposed as a useful technique to identify exercise-induced...
Lowering pulmonary wedge pressure after heart transplant: pulmonary compliance ...
Moreira, Nádia; Baptista, Rui; Costa, Susana; Franco, Fátima; Pêgo, Mariano; Antunes, ManuelBackground: Right ventricular (RV) afterload is an important risk factor for post-heart transplantation (HTx) mortality, and it results from the interaction between pulmonary vascular resistance (PVR) and pulmonary compliance (CPA). Their product, the RC time, is believed to be constant. An exception is observed in pulmonary hypertension because of elevated left ventricular (LV) filling pressures. Objectives: U...
Cardiovascular risk analysis by means of pulse morphology and clustering method...
Almeida, Vânia G.; Borba, J.; Pereira, H. Catarina; Pereira, Tânia; Correia, Carlos; Pêgo, Mariano; Cardoso, JoãoThe purpose of this study was the development of a clustering methodology to deal with arterial pressure waveform (APW) parameters to be used in the cardiovascular risk assessment. One hundred sixteen subjects were monitored and divided into two groups. The first one (23 hypertensive subjects) was analyzed using APW and biochemical parameters, while the remaining 93 healthy subjects were only evaluated through ...
Diabetes e síndromes coronárias agudas: uma abordagem prática
Monteiro, Pedro; Monteiro, Sílvia; Gonçalves, Francisco; Pêgo, MarianoA diabetes mellitus tipo 2 é actualmente reconhecida como um importante factor de risco de morbilidade e mortalidade cardiovascular, particularmente em doentes admitidos com síndromes coronárias agudas (SCA). Apesar dos recentes avanços do diagnóstico, estratificação de risco e tratamento destas entidades clínicas, a sua associação no mesmo doente continua a representar um prognóstico sombrio. O objectivo deste...