4 documents found, page 1 of 1
Molecular profiling of prognostic biomarkers in Melanoma
Jesus, Marta; Correia, Beatriz; Costa, Catarina; João, Alexandre; Lopes, José Manuel; Barata, Catarina; Soares, Paula; Pópulo, HelenaCutaneous melanoma (CM) is the most aggressive and deadliest form of skin cancer (1). Its development is influenced by the genetic background, genetic mutations and environmental factors. The three most frequent mutations of CM appear in BRAF gene, which leads to uncontrolled cell growth, in NRAS gene, that disrupts normal cell signaling, and in TERT promoter, that increases telomerase activity and play a cruci...
Trends of Cutaneous Squamous Cell Carcinoma in the Hospital of Gaia (2004-2013)
Costa Campos, Manuel António; Fernandes Massa, António; Varela, Paulo; Moreira, Ana; Sanches, Agostinho; Pópulo, Helena; Soares, PaulaIntroduction: Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and its incidence has been rising. The objective of our study was to perform a descriptive and analytical analysis of the cutaneous squamous cell carcinoma excised in the Hospital Center Vila Nova de Gaia e Espinho (CHVNGE) over a period of 10 years and establish trends (incidence, survival and mortality).Material and M...
Frequency of TERT promoter mutations in human cancers
Vinagre, João; Almeida, Ana; Pópulo, Helena; Batista, Rui; Lyra, Joana; Pinto, Vasco; Coelho, Ricardo; Celestino, Ricardo; Prazeres, Hugo; Lima, LuísReactivation of telomerase has been implicated in human tumorigenesis, but the underlying mechanisms remain poorly understood. Here we report the presence of recurrent somatic mutations in the TERT promoter in cancers of the central nervous system (43%), bladder (59%), thyroid (follicular cell-derived, 10%) and skin (melanoma, 29%). In thyroid cancers, the presence of TERT promoter mutations (when occurring tog...
Frequency of TERT promoter mutations in human cancers
Vinagre, João; Almeida, Ana; Pópulo, Helena; Batista, Rui; Lyra, Joana; Pinto, Vasco; Coelho, Ricardo; Celestino, Ricardo; Prazeres, Hugo; Lima, LuísReactivation of telomerase has been implicated in human tumorigenesis, but the underlying mechanisms remain poorly understood. Here we report the presence of recurrent somatic mutations in the TERT promoter in cancers of the central nervous system (43%), bladder (59%), thyroid (follicular cell-derived, 10%) and skin (melanoma, 29%). In thyroid cancers, the presence of TERT promoter mutations (when occurring tog...