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Clostridioides difficile is an opportunistic pathogen that can cause a range of conditions, from asymptomatic carriage to severe illness, posing a significant public health threat due to its high mortality rates and substantial healthcare costs. Traditional treatment options, including antibiotics, often fail to eradicate the infection, leading to recurrent cases that severely impact patients’ lives. Intestinal...
Introduction: Acute liver failure (ALF) is a rare disease with high mortality. Acute kidney injury (AKI) following ALF is frequent. We assessed AKI impact on long-term kidney function among ALF survivors. Methods: Observational cohort study including consecutive adult (age ≥16 years) patients with ALF or acute liver injury (ALI) admitted to a Portuguese tertiary center intensive care unit (ICU) between October ...
Subsyndromal delirium (SSD) in the Intensive Care Unit (ICU) is associated with an increased morbidity with unknown post-discharge functional and cognitive outcomes. We performed a prospective multicenter study to analyze the mental status of patients during their first 72 h after ICU admission and its trajectory, with follow-ups at 3 and 6 months after hospital discharge. Amongst the 106 included patients, SSD...
Submitted by DSpace Unilasalle (dspace@unilasalle.edu.br) on 2021-07-12T12:51:27Z No. of bitstreams: 1 Biomarkers in the ICU_ICM.pdf: 1536511 bytes, checksum: b92e569594c38890abe96f5a20acc277 (MD5); Made available in DSpace on 2021-07-12T12:51:27Z (GMT). No. of bitstreams: 1 Biomarkers in the ICU_ICM.pdf: 1536511 bytes, checksum: b92e569594c38890abe96f5a20acc277 (MD5) Previous issue date: 2021
Submitted by DSpace Unilasalle (dspace@unilasalle.edu.br) on 2021-07-27T18:59:11Z No. of bitstreams: 1 Ventilator-associated tracheobronchitis_RBTI.pdf: 133717 bytes, checksum: b2d3419a937cd75babd12c37cce076a7 (MD5); Made available in DSpace on 2021-07-27T18:59:12Z (GMT). No. of bitstreams: 1 Ventilator-associated tracheobronchitis_RBTI.pdf: 133717 bytes, checksum: b2d3419a937cd75babd12c37cce076a7 (MD5) Previou...
Submitted by DSpace Unilasalle (dspace@unilasalle.edu.br) on 2021-09-10T23:12:37Z No. of bitstreams: 1 The role of steroids in severe CAP.pdf: 232136 bytes, checksum: fc65c7581dcec5c29d337042cb681d4c (MD5); Made available in DSpace on 2021-09-10T23:12:37Z (GMT). No. of bitstreams: 1 The role of steroids in severe CAP.pdf: 232136 bytes, checksum: fc65c7581dcec5c29d337042cb681d4c (MD5) Previous issue date: 2020; ...
A fundamental step in the successful management of sepsis and septic shock is early empiric antimicrobial therapy. However, for this to be effective, several decisions must be addressed simultaneously: (1) antimicrobial choices should be adequate, covering the most probable pathogens; (2) they should be administered in the appropriate dose, (3) by the correct route, and (4) using the correct mode of administrat...
COVID-19 is an infectious disease caused by Coronavirus 2 (SARS-CoV-2) that may lead to a severe acute respiratory syndrome. Such syndrome is thought to be related, at least in part, to a dysregulation of the immune system which involves three main components: hyperactivity of the innate immune system; decreased production of type 1 Interferons (IFN) by SARS-CoV-2-infected cells, namely respiratory epithelial c...
The aim was to provide global experts ranking on priorities in diagnostic tools for VAP in clinical practice. A multiple criteria decision analysis (MCDA) was performed to identify diagnosis tools for VAP diagnosis. Priority factors were identified after literature review. An international, multidisciplinary expert panel reviewed variables and ranked diagnostic tools. Experts from ten European hospitals partici...