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Fatal Case of Progressive Mpox in a Patient with AIDS—Viral Enteropathy and Mal...

Caria, J; Vara-Luiz, F; Maia, I; Joosten, A; Val-Flores, L; Pinheiro, H; Póvoas, D; Germano, N; Maltez, F

We report a fatal case of disseminated mpox infection that progressed over more than three months in an HIV-infected patient with acquired immunodeficiency syndrome (AIDS). Mucocutaneous, pleuropulmonary, central nervous system, and gastrointestinal involvement was documented. This course of disease resembles progressive vaccinia, a formerly reported disease caused by uncontrolled replication of smallpox vaccin...


A Case of Central Nervous System Infection by Candida Famata in an Immunosuppre...

Caria, J; Leal, E; Dias, A; Pinheiro, H; Póvoas, D; Maltez, F

Invasive fungal infections caused by Candida species are increasingly observed in immunosuppressed patients. Candida albicans is the more often identified species and neurocandidiasis is associated with high mortality rates. Diagnosis and treatment of these infections are frequently challenging. We report a case of central nervous system infection caused by Candida famata in an HIV-1 infected patient. To our be...


Clinical and Epidemiological Features of Hospitalized and Ambulatory Patients w...

Caria, J; Pinto, R; Leal, E; Almeida, V; Cristóvão, G; Gonçalves, AC; Torres, M; Santos, MB; Pinheiro, H; Póvoas, D; Seixas, D; Lino, S; Cardoso, O

Monkeypox, a neglected and re-emergent zoonotic disease caused by monkeypox virus (MPXV) infection, has been endemic in Central and Western Africa for decades. More recently, an outbreak has spread to a global level, occurring in sites with no previous reported cases and being clustered among men who have sex with men, suggesting new modes of transmission. There is an urgent need for research for a better under...


Infection, Immunosuppression and Treatment of Auto-Immune Inflammatory Kidney D...

Póvoas, D

Immunosuppressive drugs are the cornerstone of treatment of auto-immune inflammatory diseases (AIIDs) with renal involvement. However, the most commonly used drugs in this setting can increase the risk of bacterial, fungal, and viral infection, and also impair immune response following vaccination. Recommendations and evidence on strategies for infection prevention in the setting of AIIDs treatment will be revi...




Tuberculosis in Liver Transplant Recipients: A Report of Eight Cases During a F...

Póvoas, D; Machado, J; Perdigoto, R; Morbey, A; Veloso, J; Glória, H; Mateus, E; Martins, A; Maltez, F; Barroso, E

Introduction: Tuberculosis incidence in Portugal ranged from 20 to 22 cases per 100 000 inhabitants between 2010 and 2014. Tuberculosis incidence in liver transplant recipients is not precisely known, but it is estimated to be higher than among the general population. Tuberculosis in liver transplant recipients is particularly challenging because of the atypical clinical presentation and side effects of the ant...


Tuberculose Multirresistente por Estirpes da Família Beijing, em Doentes de Lis...

Maltez, F; Martins, T; Póvoas, D; Cabo, J; Peres, H; Antunes, F; Perdigão, J; Portugal, I

Introdução: As estirpes de Mycobacterium tuberculosis da família Beijing estão associadas à multirresistência. As estirpes da família Lisboa prevalecem entre os doentes com tuberculose multirresistente e extensivamente resistente desta região, mas vários estudos documentam a presença da família Beijing, embora desconhecendo-se as características dos doentes donde foram isoladas. Material e Métodos: Estudo retro...



Acute Bivalvular Left-Sided Methicillin-Resistant Staphylococcus Aureus Endocar...

Póvoas, D; Figueiredo, M; Murinello, A; Damásio, H; Ramos, A; Rodrigues, N; Sousa, J; Carvalho, F; Peres, H; Gomes, P

Infective endocarditis (IE) is now rare in developed countries, but its prevalence is higher in elderly patients with prosthetic valves, diabetes, renal impairment, or heart failure. An increase in health-care associated IE (HCAIE) has been observed due to invasive maneuvers (30% of cases). Methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus are the most common agents in HCAIE, causing high mort...


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