3 documents found, page 1 of 1
Reprogramming iPSCs to study age-related diseases: models, therapeutics, and cl...
Esteves, Filipa; Brito, David; Rajado, Ana Teresa; Silva, Nádia; Apolónio, Joana; Roberto, Vania Palma; Araújo, Inês Maria; Nóbrega, ClévioThe unprecedented rise in life expectancy observed in the last decades is leading to a global increase in the ageing population, and age-associated diseases became an increasing societal, economic, and medical burden. This has boosted major efforts in the scientific and medical research communities to develop and improve therapies to delay ageing and age-associated functional decline and diseases, and to expand...
Cell–fibronectin interactions and actomyosin contractility regulate the segment...
Gomes De Almeida, Patrícia; Rifes, Pedro; Jesus, Ana Patrícia; Pinheiro, Gonçalo; P. Andrade, Raquel; Thorsteinsdóttir, SólveigFibronectin is essential for somite formation in the vertebrate embryo. Fibronectin matrix assembly starts as cells emerge from the primitive streak and ingress in the unsegmented presomitic mesoderm (PSM). PSM cells undergo cyclic waves of segmentation clock gene expression, followed by Notch-dependent upregulation of meso1 in the rostral PSM which induces somite cleft formation. However, the relevance of the ...
The T-box transcription factor brachyury behaves as a tumor suppressor in gliomas
Pinto, Filipe; Costa, Angela M.; Santos, Gisele C.; Matsushita, Marcus M.; Costa, Sandra; Silva, Viviane A. O.; Miranda-Goncalves, VeraThe oncogene brachyury (TBXT) is a T-box transcription factor that is overexpressed in multiple solid tumors and is associated with tumor aggressiveness and poor patient prognosis. Gliomas comprise the most common and aggressive group of brain tumors, and at the present time the functional and clinical impact of brachyury expression has not been investigated previously in these neoplasms. Brachyury expression (...