3 documents found, page 1 of 1
Clostridioides difficile Toxin A-Induced Wnt/β-Catenin Pathway Inhibition Is Me...
Martins, Conceição S.; Costa, Deiziane V. S.; Lima, Bruno B.; Leitäo, Renata Ferreira de Carvalho; Freire, Gildênio E.; Silva, Guilherme F. M.Clostridioides difficile toxin A (TcdA) has been shown to inhibit cellular Wnt signaling, the major driving force behind the proliferation of epithelial cells in colonic crypts, likely through the inhibition of β-catenin nuclear translocation. Herein, we aimed to advance the understanding of this mechanism by replicating the findings in vivo and by investigating the specific role of Rac1, a member of the Rho GT...
Lactobacillus reuteri DSM 17938 protects agains gastric damage induced by ethan...
Oliveira, Ana P.; Souza, Luan K. M.; Araújo, Thiago S. L.; Araújo, Simone de; Nogueira, Kerolayne M.; Sousa, Francisca Beatriz M.; Silva, Renan O.This study aimed to evaluate the effect of Lactobacillus reuteri DSM 17938 (DSM) on ethanol-induced gastric injury, and if its possible mechanism of action is related to inhibiting the transient receptor potential vanilloid type 1 (TRPV1). We evaluated the effect of supplementing 108 CFU g body wt1 day1 of DSM on ethanol-induced gastric injury. DSM significantly reduced the ulcer area (1.940 1.121 mm2) with 3 d...
Epiisopiloturine hydrochloride, an imidazole alkaloid isolated from Pilocarpus ...
Nicolau, Lucas Antonio Duarte; Carvalho, Nathalia S.; Pacífico, Dvison M.; Lucetti, Larisse T.; Aragão, Karoline Sabóia; Véras, Leiz M.C.Objective This study aimed to investigate the protective effect of epiisopiloturine hydrochloride (EPI), an imidazole alkaloid, on NAP-induced gastrointestinal damage in rats. Methods Initially, rats were pretreated with 0.5% carboxymethylcellulose (vehicle) or EPI (3, 10 and 30 mg/kg, p.o. or i.p., groups 3–5, respectively) twice daily, for 2 days. After 1 h, NAP (80 mg/kg, p.o.) was given. The control group r...