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Integrated Use of Bioaccumulation, Genotoxic, and Haematological Endpoints to A...

Mieiro, CL; Coelho, JP; Reis, AT; Castro, D; Figueira, P; Martinho, F; Pardal, MA; Pereira, E; Pacheco, M; Lopes, CB

Biosorption successfully remediates saline water contaminated with legacy contaminants, but its effects on the health of marine organisms remain unclear. Therefore, our aim was to address this knowledge gap with data on the accumulation ability, as well as the cytogenetic and biochemical effects in turbot (Scophthalmus maximus). To this end, we exposed turbot for seven days to a mixture of remediated metals (Re...


The red seaweed Grateloupia turuturu prevents epidermal dysplasia in HPV16-tran...

Almeida, J; Ferreira, T; Santos, S; Pires, MJ; Gil da Costa, RM; Medeiros, R; Bastos, MMSM; Neuparth, MJ; Faustino-Rocha, AI; Abreu, A; Pereira, R

Abstract: The role of dietary profiles in promoting or reducing the risk of multiple types of cancer is increasingly clear, driving the search for balanced foods and nutraceuticals. The red seaweed Grateloupia turuturu has been used as human food showing a balanced nutritional profile. This study aims to test in vivo chemopreventive effects of G. turuturu against cutaneous pre-malignant lesions in transgenic mi...


Oxidative stress profiles in brain point out a higher susceptibility of fish to...

Cardoso, O; Puga, S; Brandão, F; Canário, J; O'Driscoll, NJ; Santos, MA; Pacheco, M; Pereira, P

This study examines, for the first time, the neurotoxicity of Hg(II) and MeHg in fish (Diplodus sargus) in a time-course comparative perspective and considering realistic exposure levels and routes. Both forms followed an identical time-variation pattern of accumulation in the brain, but dietary MeHg was more efficiently transported to the brain. MeHg was substantially eliminated from the brain in 28 days of de...


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