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Candida albicans chitinase 3 with potential as a vaccine antigen: production, p...

Barbosa, Augusto Alexandre Costa; Ferreira, Diogo; Pacheco, Maria Inês; Casal, Margarida; Duarte, Henrique Oliveira; Gomes, Catarina

Chitinases are widely studied enzymes that have already found widespread application. Their continued development and valorisation will be driven by the identification of new and improved variants and/or novel applications bringing benefits to industry and society. We previously identified a novel application for chitinases wherein the Candida albicans cell wall surface chitinase 3 (Cht3) was shown to have pote...


Design of a lipid nano-delivery system containing recombinant Candida albicans ...

Costa-Barbosa, Augusto; Pacheco, Maria Inês; Carneiro, Catarina; Botelho, Cláudia M.; Gomes, Andreia C; Real Oliveira, M. Elisabete C.D.; Collins, Tony

Opportunistic fungi cause lethal systemic infections and impose high medical costs to health systems. The World Health Organization has recognized the importance of fungal infections, including them in its global priority list guiding research, development, and discovery of new therapeutic approaches. Fungal vaccine development has been proposed as one of the treatment and prevention strategies in the last deca...


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