52 documents found, page 1 of 6
Synthesis, Characterization, and Biological Effects of Chloro-Cathinones: Toxic...
Gomes, Ana Patrícia; Ferro, Raquel; Pinto, Daniela; Silva, Joana; Alves, Celso; Pacheco, Rita; Gaspar, HelenaCathinones, a class of synthetic new psychoactive substances (NPSs), continue to emerge and pose public threats. Government control efforts often lead to the emergence of new isomers, which have adverse repercussions on NPSs identification and risk prediction. This work reports on the synthesis and structural characterization of twenty chloro-cathinones, including different isomers, to create analytical data to...
Exploring the hypocholesterolemic potential of a fucus vesiculosus extract: Omi...
André, Rebeca; Pacheco, Rita; Santos, Hugo M.; Serralheiro, Maria LuísaHigh blood cholesterol levels are a major risk factor for cardiovascular diseases. A purified aqueous extract of Fucus vesiculosus, rich in phlorotannins and peptides, has been described for its potential to inhibit cholesterol biosynthesis and intestinal absorption. In this work, the effect of this extract on intestinal cells' metabolites and proteins was analysed to gain a deeper understanding of its mode of ...
Exploring the Hypocholesterolemic Potential of a Fucus vesiculosus Extract: Omi...
Rebeca, André; Pacheco, Rita; Santos, Hugo M.; Serralheiro, Maria LuisaHigh blood cholesterol levels are a major risk factor for cardiovascular diseases. A purified aqueous extract of Fucus vesiculosus, rich in phlorotannins and peptides, has been described for its potential to inhibit cholesterol biosynthesis and intestinal absorption. In this work, the effect of this extract on intestinal cells' metabolites and proteins was analysed to gain a deeper understanding of its mode of ...
Sustainable synthesis, antiproliferative and acetylcholinesterase inhibition of...
Cabral, Rafaela G.; Viegas, Gonçalo; Pacheco, Rita; Sousa, Ana Catarina; Robalo, Maria PaulaThis work describes the design, sustainable synthesis, evaluation of electrochemical and biological properties against HepG2 cell lines, and AChE enzymes of different substituted derivatives of 1,4- and 1,2-naphthoquinones (NQ). A microwave-assisted protocol was optimized with success for the synthesis of the 2-substituted-1,4-NQ series and extended to the 4-substituted-1,2-NQ family, providing an alternative a...
The hypocholesterolemic potential of the edible algae fucus vesiculosus: Proteo...
André, Rebeca; Pacheco, Rita; Alves, Ana Catarina; Santos, Hugo M. M.; Bourbon, Mafalda; Serralheiro, Maria LuisaA brown seaweed consumed worldwide, Fucus vesiculosus, has been used to prevent atherosclerosis and hypercholesterolemia, among other uses. However, the mechanisms of action that lead to these effects are not yet fully understood. This work aims to study the in vitro effect of an aqueous extract of F. vesiculosus, previously characterized as rich in phlorotannins and peptides, on the expression of different pro...
Anti-hypercholesterolemia effects of edible seaweed extracts and metabolomic ch...
Coelho, Mariana; Pacheco, RitaHypercholesterolemia is a major risk for the development of cardiovascular diseases (CVDs), the main cause of mortality worldwide, and it is characterized by high levels of circulating cholesterol. The drugs currently available for hypercholesterolemia control have several side effects, so it is necessary to develop new effective and safer therapies. Seaweeds serve as sources of several bioactive compounds with...
Synthesis and the in vitro evaluation of antitumor activity of novel thiobenzan...
Álvaro Martins, Maria Joao; Railean, Violeta; Martins, Filomena; Machuqueiro, Miguel; Pacheco, Rita; Santos, SusanaCancer is a generic term for a large group of diseases that are the second-leading cause of death worldwide, accounting for nearly 10 million deaths in 2020. Melanoma is a highly aggressive skin tumor with an increasing incidence and poor prognosis in the metastatic stage. Breast cancer still stands as one of the major cancer-associated deaths among women, and diagnosed cases are increasing year after year worl...
Edible seaweeds extracts: characterization and functional properties for health...
Coelho, Mariana; Duarte, Ana Patrícia; Pinto, Sofia; Botelho, Hugo M.; Reis, Catarina; Serralheiro, Maria Luisa; Pacheco, RitaSeaweeds are popular foods due to claimed beneficial health effects, but for many there is a lack of scientific evidence. In this study, extracts of the edible seaweeds Arame, Nori, and Fucus are compared. Our approach intends to clarify similarities and differences in the health properties of these seaweeds, thus contributing to target potential applications for each. Additionally, although Arame and Fucus sea...
Avaliação da sustentabilidade da cadeia agroalimentar: plataforma siBIO
Santos Coelho, Rosa; Ferreira, Mafalda; Pacheco, Rita; Valin, Isabel; Oliveira, MargaridaOs consumidores, cada vez mais informados e exigentes face à segurança alimentar, à qualidade e ao acesso aos alimentos, valorizam a sustentabilidade da cadeia agroalimentar. Os técnicos e os decisores estão atentos às tendências para irem ao encontro das exigências dos consumidores. O projeto BIOMA tem, como um dos objetivos, promover a avaliação da sustentabilidade das empresas (produção primária, indústria t...
Nanoformulation of seaweed eisenia bicyclis in albumin nanoparticles targeting ...
Pinto, Sofia; Gaspar, Maria Manuela; Ascensão, Lia; Faísca, Pedro; Reis, Catarina; Pacheco, RitaNatural products, especially those derived from seaweeds, are starting to be seen as effective against various diseases, such as cardiovascular diseases (CVDs). This study aimed to design a novel oral formulation of bovine albumin serum nanoparticles (BSA NPs) loaded with an extract of Eisenia bicyclis and to validate its beneficial health effects, particularly targeting hypercholesterolemia and CVD prevention....