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Engineered shape-tunable copper-coordinated nanoparticles for macrophage reprog...

Gao, Han; Cheng, Ruoyu; Cardoso, Inês; Lobita, Maria; Pacheco-Fernández, Idaira; Bártolo, Raquel; Rodrigues, L. R.; Hirvonen, Jouni; Santos, Hélder A.

The immune system safeguards as primary defense by recognizing nanomaterials and maintaining homeostasis, gaining a deeper understanding of these interactions may change the treating paradigm of immunotherapy. Here, we adopted copper as the principal component of nanoparticles (NPs), given its features of coordination with different benezenecarboxylate ligands to form metalorganic frameworks and complexes with ...


Insights into coacervative and dispersive liquid-phase microextraction strategi...

Pacheco-Fernández, Idaira; González-Martín, Raúl; Silva, Francisca A. e; Freire, Mara G.; Pino, Verónica

Since the development of liquid-phase microextraction (LPME), different LPME modes depending on the experimental set-up to carry out the extraction have been described. Dispersive liquid-liquid microextraction (DLLME), in which a small amount of the water-insoluble extraction solvent is dispersed in the sample, is the most successful mode in terms of number of applications reported. Advances within DLLME have b...


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