2 documents found, page 1 of 1
Current screening methodologies in drug discovery for selected human diseases
Lage O.M.; Ramos M.C.; Calisto R.; Almeida E.; Vasconcelos V.; Vicente F.The increase of many deadly diseases like infections by multidrug-resistant bacteria implies re-inventing the wheel on drug discovery. A better comprehension of the metabolisms and regulation of diseases, the increase in knowledge based on the study of disease-born microorganisms’ genomes, the development of more representative disease models and improvement of techniques, technologies, and computation applied ...
Planctomycetes as novel source of bioactive molecules
Graça A.P.; Calisto R.; Lage O.M.Marine environments are a fruitful source of bioactive compounds some of which are the newest leading drugs in medicinal therapeutics. Of particular importance are organisms like sponges and macroalgae and their associated microbiome. Planctomycetes, abundant in macroalgae biofilms, are promising producers of bioactive compounds since they share characteristics, like large genomes and complex life cycles, with ...