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New 4-aminoacridine-cinnamic acid conjugates as multi-stage antimalarial hits

Fonte, Mélanie; Fontinha, Diana; Moita, Diana; Prades, Omar; Padilla, Yunuen; Ferraz, Ricardo; Fernàndez-Busquets, Xavier; Prudêncio, Miguel

The eradication of malaria remains to be achieved, mainly due to the continued spread of drugresistant parasites. To overcome this, multi-stage drugs have been prioritized in antimalarial drug discovery, since targeting more than one process in the Plasmodium’s life cycle may increase efficiency, while decreasing the chances of resistance emergence by the parasite. Quinacrine (QN) was the first synthetic antipl...

Date: 2022   |   Origin: Repositório Científico do Instituto Politécnico do Porto
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