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Presence of highly oncogenic human papillomavirus in the oral mucosa of asympto...
Machado,Ana Paula; Almeida,Flávia Gatto de; Bonin,Camila Mareti; Prata,Thiago Theodoro Martins; Ávilla,Leandro SobrinhoOBJECTIVES: The aim of this study was to identify highly oncogenic forms of human papillomavirus in the oral mucosa of asymptomatic men.METHODS: In this study, we analyzed samples of exfoliated cells from the oral cavity of 559 asymptomatic men. DNA-human papillomavirus was detected using the consensus primers PGMY09/11; viral genotyping was performed using type-specific PCR and restriction fragment length poly...
Glucocorticoid-induced tumor necrosis factor receptor expression in patients wi...
Padovani,Cacilda Tezelli Junqueira; Bonin,Camila Mareti; Tozetti,Ines Aparecida; Ferreira,Alda Maria Teixeira; Fernandes,Carlos Eurico dos SantosIntroduction The progression of human papillomavirus (HPV) infection in the anogenital tract has been associated with the involvement of cells with regulatory properties. Evidence has shown that glucocorticoid-induced tumor necrosis factor receptor (GITR) is an important surface molecule for the characterization of these cells and proposes that GITR ligand may constitute a rational treatment for many cancer typ...
S100, CD68, and MHC class II molecule expression in cervical high- and low-grad...
Cassandri,Fernanda; Tozetti,Inês Aparecida; Fernandes,Carlos Eurico dos Santos; Almeida,Flávia Gatto de; Falcão,Gustavo RibeiroINTRODUCTION: Some human papillomavirus (HPV) types are involved in malignant processes in the cervical epithelium, with 99% of cases attributed to oncogenic HPV infection. This study aimed to detect S100, CD68, and major histocompatibility complex class II (MHC-II) molecules in cervical uterine epithelial samples in patients with high- and low-grade lesions induced by HPV. METHODS: Fifty-eight samples from pat...
Linfócitos CD4, CD8 e células NK no estroma da cérvice uterina de mulheres infe...
Alves,Daniella Borges; Tozetti,Inês Aparecida; Gatto,Flávia Almeida; Cassandri,Fernanda; Ferreira,Alda Maria TeixeiraINTRODUÇÃO: A resposta imune pode ser um elemento chave para a progressão ou remissão da infecção pelo papilomavírus humano (HPV) no estroma da cérvice uterina. Este estudo objetivou quantificar no estroma cervical a presença de linfócitos T CD4, CD8 e células NK, por imunohistoquímica, em lesões de alto e baixo grau em pacientes infectadas por HPV MÉTODOS: Utilizou-se 56 amostras de biópsia da estroma cervical...