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Influence of ?S-globin haplotypes and hydroxyurea on tumor necrosis factor-alph...
Laurentino,Marília Rocha; Maia Filho,Pedro Aurio; Barbosa,Maritza Cavalcante; Bandeira,Izabel Cristina Justino; Rocha,Lilianne Brito da SilvaBackground: Sickle cell anemia is a chronic inflammatory disease characterized by an increased production of proinflammatory cytokines including tumor necrosis factor-alpha. Hydroxyurea, by decreasing the polymerization of hemoglobin, reduces inflammatory states. The effect of the genetic polymorphisms of sickle cell patients on tumor necrosis factor-alpha levels remains unknown. Objective: The aim of this stud...
Tumor suppressor p53 protein expression: prognostic significance in patients wi...
Duarte,Fernando Barroso; Gonçalves,Romelia Pinheiro; Barbosa,Maritza Cavalcante; Rocha Filho,Francisco Dário; Santos,Talyta Ellen de Jesus dosBACKGROUND: At the time of diagnosis, more than 50% of patients with myelodysplastic syndrome have a normal karyotype and are classified as having a favorable prognosis. However, these patients often show very variable clinical outcomes. Furthermore, current diagnostic tools lack the ability to look at genetic factors beyond karyotyping in order to determine the cause of this variability.OBJECTIVE: To evaluate ...
Dengue: profile of hematological and biochemical dynamics
Azin,Francisca Raimunda F. Guerreiro; Gonçalves,Romelia Pinheiro; Pitombeira,Maria Helena da Silva; Lima,Danielle Malta; Castelo Branco,IvoAIM: The objective of this study was to correlate laboratory tests during the evolution of dengue fever, comparing frequencies between the different clinical forms in order to use test results to predict the severity of the disease. METHODS: This is an observational, descriptive and retrospective study of 154 patients with clinical and serological diagnoses of dengue fever who, in the period from January to May...
Serum concentrations of nitrite and malondialdehyde as markers of oxidative str...
Petrola,Maria Juracy; Castro,Alana Joselina Montenegro de; Pitombeira,Maria Helena da Silva; Barbosa,Maritza Cavalcante; Quixadá,Acy Telles de SouzaBACKGROUND: Chronic myeloid leukemia is a neoplasm characterized by clonal expansion of hematopoietic progenitor cells resulting from the (9:22)(q34,11) translocation. The tyrosine kinase abl fusion protein,the initial leukemogenic event in chronic myeloid leukemia, is constitutively activated thus inducing the production of reactive oxygen species. Of particular relevance is the fact that an increase in reacti...
Bone marrow cytomorphological changes in patients co-infected with visceral lei...
Castro,Alana Jocelina Montenegro de; Gonçalves,Romelia Pinheiro; Pitombeira,Maria Helena da SilvaVisceral leishmaniasis (VL) is a severe systemic infectious disease.(1) It has been recognized as an opportunistic disease in patients infected with human immunodeficiency virus (HIV).(2,3) The analysis of the bone marrow of patients co-infected with VL and HIV showed dysplasia of erythroid, granulocytic and megakaryocytic lineages (Figure 1), besides the presence of plasmacytosis, cytoplasmic bodies, hemophago...