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Phytosterols: From Preclinical Evidence to Potential Clinical Applications

Salehi, B; Quispe, C; Sharifi-Rad, J; Martins, N; Nigam, M; Mishra, AP; Konovalov, DA; Orobinskaya, V; Abu-Reidah, IM; Zam, W; Sharopov, F; Venneri, T

Phytosterols (PSs) are plant-originated steroids. Over 250 PSs have been isolated, and each plant species contains a characteristic phytosterol composition. A wide number of studies have reported remarkable pharmacological effects of PSs, acting as chemopreventive, anti-inflammatory, antioxidant, antidiabetic, and antiatherosclerotic agents. However, PS bioavailability is a key issue, as it can be influenced by...


Phenolic Bioactives as Antiplatelet Aggregation Factors: The Pivotal Ingredient...

Sharifi-Rad, J; Quispe, C; Zam, W; Kumar, M; Cardoso, SM; Pereira, OR; Ademiluyi, AO; Adeleke, O; Moreira, AC; Živkovic, J; Noriega, F; Ayatollahi, SA

Cardiovascular diseases (CVD) are one of the main causes of mortality in the world. The development of these diseases has a specific factor-alteration in blood platelet activation. It has been shown that phenolic compounds have antiplatelet aggregation abilities and a positive impact in the management of CVD, exerting prominent antioxidant, anti-inflammatory, antitumor, cardioprotective, antihyperglycemic, and ...


Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safet...

Sharifi-Rad, J; Rayess, YE; Rizk, AA; Sadaka, C; Zgheib, R; Zam, W; Sestito, S; Rapposelli, S; Neffe-Skocinska, K; Zielinska, D; Salehi, B; Setzer, WN

Curcumin, a yellow polyphenolic pigment from the Curcuma longa L. (turmeric) rhizome, has been used for centuries for culinary and food coloring purposes, and as an ingredient for various medicinal preparations, widely used in Ayurveda and Chinese medicine. In recent decades, their biological activities have been extensively studied. Thus, this review aims to offer an in-depth discussion of curcumin application...


Current trends on seaweeds: Looking at chemical composition, phytopharmacology,...

Salehi, B; Sharifi-Rad, J; Seca, AML; Pinto, DCGA; Michalak, I; Trincone, A; Mishra, AP; Nigam, M; Zam, W; Martins, N

Seaweeds have received huge interest in recent years given their promising potentialities. Their antioxidant, anti-inflammatory, antitumor, hypolipemic, and anticoagulant effects are among the most renowned and studied bioactivities so far, and these effects have been increasingly associated with their content and richness in both primary and secondary metabolites. Although primary metabolites have a pivotal im...


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