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Natural products as new antimitotic compounds for anticancer drug development
Paier, Carlos Roberto Koscky; Maranhão, Sarah Sant’Anna; Carneiro, Teiliane Rodrigues; Lima, Lídia Moreira; Rocha, Danilo DamascenoCell cycle control genes are frequently mutated in cancer cells, which usually display higher rates of proliferation than normal cells. Dysregulated mitosis leads to genomic instability, which contributes to tumor progression and aggressiveness. Many drugs that disrupt mitosis have been studied because they induce cell cycle arrest and tumor cell death. These antitumor compounds are referred to as antimitotics....
Data: 2019
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Origem: Oasisbr