3 documents found, page 1 of 1
Microglial Activation in the Retina of a Triple-Transgenic Alzheimer's Disease ...
Salobrar-García, Elena; Rodrigues-Neves, Ana C.; Ramírez, Ana I.; de Hoz, Rosa; Fernández-Albarral, José A.; López-Cuenca, Inés; Ramírez, José M.Alzheimer's disease (AD) is the most common type of dementia in the world. The main biomarkers associated with AD are protein amyloid-β (Aβ) plaques and protein tau neurofibrillary tangles, which are responsible for brain neuroinflammation mediated by microglial cells. Increasing evidence has shown that the retina can also be affected in AD, presenting some molecular and cellular changes in the brain, such as m...
Elevated Pressure Changes the Purinergic System of Microglial Cells
Rodrigues-Neves, Ana C.; Aires, Inês D.; Vindeirinho, Joana R.; Boia, Raquel; Madeira, Maria H.; Gonçalves, Francisco Q.; Cunha, Rodrigo A.Glaucoma is the second cause of blindness worldwide and is characterized by the degeneration of retinal ganglion cells (RGCs) and optic nerve atrophy. Increased microglia reactivity is an early event in glaucoma that may precede the loss of RGCs, suggesting that microglia and neuroinflammation are involved in the pathophysiology of this disease. Although global changes of the purinergic system have been reporte...
Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate micr...
Boia, Raquel; Elvas, Filipe; Madeira, Maria H.; Aires, Inês D.; Rodrigues-Neves, Ana C.; Tralhão, Pedro; Szabó, Eszter C; Baqi, YounisTransient retinal ischemia is a major complication of retinal degenerative diseases and contributes to visual impairment and blindness. Evidences indicate that microglia-mediated neuroinflammation has a key role in the neurodegenerative process, prompting the hypothesis that the control of microglia reactivity may afford neuroprotection to the retina against the damage induced by ischemia-reperfusion (I-R). The...