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Review of Piezoelectrical Materials Potentially Useful for Peripheral Nerve Repair

Casal, D; Casimiro, MH; Ferreira, L; Leal, JP; Rodrigues, G; Lopes, R; Lino Moura, D; Gonçalves, L; Lago, J; Pais, D; Santos, P

It has increasingly been recognized that electrical currents play a pivotal role in cell migration and tissue repair, in a process named "galvanotaxis". In this review, we summarize the current evidence supporting the potential benefits of electric stimulation (ES) in the physiology of peripheral nerve repair (PNR). Moreover, we discuss the potential of piezoelectric materials in this context. The use of these ...


Anatomical Basis, Histological Findings and Hemodinamics in the Modern Perfusio...

Júnior, E; Bettencourt-Pires, M; Alves, S; Casal, D; Pais, D; Goyri O’neill, J; Vassilenko, V

sSeveral modern human cadaveric fixation methods are subject to permanent evaluation. Formaldehyde is the oldest and still the most widely used method of embalming. However, the International Agency for Research on Cancer has proven its high carcinogenic potential and its use was banned, with the recommendation of research for better alternatives in the conservation of corpses. The embalming method of excellenc...


Cancer During Pregnancy: How to Handle the Bioethical Dilemmas?—A Scoping Revie...

Alpuim Costa, D; Nobre, JG; de Almeida, SB; Ferreira, MH; Gonçalves, I; Braga, S; Pais, D

Date: 2020   |   Origin: Saúde - CUF

BD-2 and BD-3 Increase Skin Flap Survival in a Model of Ischemia and Pseudomona...

Casal, D; Iria, I; Ramalho, JS; Alves, S; Mota-Silva, E; Mascarenhas-Lemos, L; Pontinha, C; Guadalupe-Cabral, M; Ferreira-Silva, J; Ferraz-Oliveira, M

The main aim of this work was to study the usefulness of human β-defensins 2 (BD-2) and 3 (BD-3), which are part of the innate immune system, in the treatment of infected ischemic skin flaps. We investigated the effect of transducing rat ischemic skin flaps with lentiviral vectors encoding human BD-2, BD-3, or both BD-2 and BD-3, to increase flap survival in the context of a P. aeruginosa infection associated w...


Reconstruction of a Long Defect of the Ulnar Artery and Nerve with an Arteriali...

Casal, D; Pais, D; Mota-Silva, E; Pelliccia, G; Iria, I; Videira, P; Mendes, MM; Goyri-O'Neill, J; Mouzinho, MM

There is evidence that nerve flaps are superior to nerve grafts for bridging long nerve defects. Moreover, arterialized neurovenous flaps (ANVFs) have multiple potential advantages over traditional nerve flaps in this context. This paper describes a case of reconstruction of a long defect of the ulnar artery and nerve with an arterialized neurovenous free flap and presents a literature review on this subject. A...


A Stab Wound to the Axilla Illustrating the Importance of Brachial Plexus Anato...

Casal, D; Cunha, T; Pais, D; Iria, I; Almeida, MA; Millan, G; Videira e Castro, J; Goyri-O'Neill, J

BACKGROUND:Although open injuries involving the brachial plexus are relatively uncommon, they can lead to permanent disability and even be life threatening if accompanied by vascular damage. We present a case report of a brachial plexus injury in which the urgency of the situation precluded the use of any ancillary diagnostic examinations and forced a rapid clinical assessment. CASE PRESENTATION: We report a ca...


Optimization of an Arterialized Venous Fasciocutaneous Flap in the Abdomen of t...

Casal, D; Mota-Silva, E; Pais, D; Iria, I; Videira, P; Tanganho, D; Alves, S; Mascarenhas-Lemos, L; Martins Ferreira, J; Ferraz-Oliveira, M

BACKGROUND: Although numerous experimental models of arterialized venous flaps (AVFs) have been proposed, no single model has gained widespread acceptance. The main aim of this work was to evaluate the survival area of AVFs produced with different vascular constructs in the abdomen of the rat. METHODS: Fifty-three male rats were divided into 4 groups. In group I (n = 12), a 5-cm-long and 3-cm-wide conventional ...


Blood Supply to the Integument of the Abdomen of the Rat: A Surgical Perspective

Casal, D; Pais, D; Iria, I; Videira, P; Mota-Silva, E; Alves, S; Mascarenhas-Lemos, L; Pen, C; Vassilenko, V; Goyri-O'Neill, J

BACKGROUND: Many fundamental questions regarding the blood supply to the integument of the rat remain to be clarified, namely the degree of homology between rat and humans. The aim of this work was to characterize in detail the macro and microvascular blood supply to the integument covering the ventrolateral aspect of the abdominal wall of the rat. METHODS: Two hundred five Wistar male rats weighing 250-350 g w...


Stab Injury to the Preauricular Region With Laceration of the External Carotid ...

Casal, D; Pelliccia, G; Pais, D; Carrola-Gomes, D; Almeida, MA; Videira e Castro, J; Goyri-O'Neill, J

BACKGROUND: Open injuries to the face involving the external carotid artery are uncommon. These injuries are normally associated with laceration of the facial nerve because this nerve is more superficial than the external carotid artery. Hence, external carotid artery lesions are usually associated with facial nerve dysfunction. We present an unusual case report in which the patient had an injury to this artery...


Outcomes and Satisfaction of Two Optional Cadaveric Dissection Courses: a 3-Yea...

Pais, D; Casal, D; Mascarenhas-Lemos, L; Barata, P; Moxham, B; Goyri-O'Neill, J

Teaching time dedicated to anatomy education has been reduced at many medical schools around the world, including Nova Medical School in Lisbon, Portugal. In order to minimize the effects of this reduction, the authors introduced two optional, semester-long cadaveric dissection courses for the first two years of the medical school curriculum. These courses were named Regional Anatomy I (RAI) and Regional Anatom...


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