2 documents found, page 1 of 1
Sternal Mass: A Rare Case of Primary Hodgkin Lymphoma of The Bone
Diogo, Cláudia; Antunes, Daniela; Pais, Tiago; Rodrigues, Ana Isabel; Ponciano, Ana; Monteiro, Joana RaquelSternal tumour lesions remain a challenge in clinical practice. Due to multiple etiologies, it can be difficult to diagnose primary bone Hodgkin lymph, often misdiagnosed as tuberculosis or eosinophilic granuloma. The authors report the case of a 32-year-old patient with non-specific sternal chest pain that had lasted approximately one year as the initial presentation of primary Hodgkin lymphoma of the sternum,...
NMR solution structure of a cold-adapted thiol-disulfide oxidoreductase
Collins, Tony; Matzapetakis, Manolis; Pais, Tiago; Lamosa, Pedro; Santos, HelenaPsychrophilic enzymes produced by cold-adapted micro-organisms have successfully overcome the low temperature challenge and adapted to maintain high catalytic rates in their permanently cold environments. The current consensus is that this high activity at low temperatures is mainly achieved through an increase in the flexibility of the protein structure, thereby allowing for the molecular motions necessary for...