25 documents found, page 1 of 3
Enzymatic hydrolysis allows an integral valorization of nannochloropsis oceanic...
Cunha, Sara A.; Coscueta, Ezequiel R.; Alexandre, Agostinho M. R. C.; Partidário, Ana Maria Carvalho; Fernández, Naiara; Paiva, AlexandreNannochloropsis oceanica is a microalga with relevant protein content, making it a potential source of bioactive peptides. Furthermore, it is also rich in fatty acids, with a special focus on eicosapentaenoic acid, an omega-3 fatty acid mainly obtained from marine animal sources, with high importance for human health. N. oceanica has a rigid cell wall constraining protein extraction, thus hydrolyzing it may hel...
Evaluation of the biological potential of Himanthalia elongata (L.) S.F.Gray an...
Gomes, Inês; Rodrigues, Helena; Rodrigues, Carla; Marques, Marta; Paíga, Paula; Paiva, Alexandre; Simões, Pedro; Cruz Fernandes, VirgíniaNeuroprotection is a need that remains unmet in treating chronic neurodegenerative disorders, despite decades of extensive research. To find new neuroprotective compounds, extracts of Himanthalia elongata (L.) S.F.Gray and of Eisenia bicyclis (Kjellman) Setchell were obtained through subcritical water extraction applying a four-step temperature gradient. The fractions obtained were screened against brain enzyme...
Evaluation of the Biological Potential of Himanthalia elongata (L.) S.F.Gray an...
Gomes, Inês; Rodrigues, Helena; Rodrigues, Carla; Oliveira, Marta Marques; Paíga, Paula; Paiva, Alexandre; Simões, Pedro; Fernandes, Virgínia CruzNeuroprotection is a need that remains unmet in treating chronic neurodegenerative disorders, despite decades of extensive research. To find new neuroprotective compounds, extracts of Himanthalia elongata (L.) S.F.Gray and of Eisenia bicyclis (Kjellman) Setchell were obtained through subcritical water extraction applying a four-step temperature gradient. The fractions obtained were screened against brain enzyme...
Multi-step subcritical water extracts of fucus vesiculosus l. And codium toment...
Soares, Cristina; Paíga, Paula; Marques, Marta; Neto, Tânia; Carvalho, Ana Paula; Paiva, Alexandre; Simões, Pedro; Costa, Leonor; Bernardo, AnaMental health and active aging are two of the main concerns in the 21st century. To search for new neuroprotective compounds, extracts of Codium tomentosum Stackhouse and Fucus vesiculosus L. were obtained through multi-step (four step) subcritical water extraction using a temperature gradient. The safety assessment of the extracts was performed by screening pharmaceutical compounds and pesticides by UHPLC-MS/M...
Multi-step subcritical water extracts of fucus vesiculosus L. and Codium toment...
Soares, Cristina; Paiga, Paula; Marques, Marta; Neto, Tânia; Carvalho, Ana Paula; Paiva, Alexandre; Simões, Pedro; Costa, Leonor; Bernardo, AnaMental health and active aging are two of the main concerns in the 21st century. To search for new neuroprotective compounds, extracts of Codium tomentosum Stackhouse and Fucus vesiculosus L. were obtained through multi-step (four step) subcritical water extraction using a temperature gradient. The safety assessment of the extracts was performed by screening pharmaceutical compounds and pesticides by UHPLC-MS/M...
Therapeutic role of deep eutectic solvents based on menthol and saturated fatty...
Silva, Joana M.; Pereira, Carolina Jesus Vieira; Mano, Francisca; Silva, Eduardo; Castro, Vânia Isabel Baptista; Sá-Nogueira, Isabel; Reis, R. L.The breakthroughs achieved in green solvents promote the emergence of therapeutic deep eutectic solvents (THEDES), which possess intriguing possible applications in the biomedical field. Herein, the main aim was to unravel the biomedical potential of hydrophobic THEDES based in menthol and saturated fatty acids with different chain lengths (e.g., stearic acid (SA), myristic acid (MA), and lauric acid (LA)). Our...
Unveil the anticancer potential of limomene based therapeutic deep eutectic sol...
Pereira, Carolina Jesus Vieira; Silva, Joana M.; Rodrigues, Liliana; Reis, R. L.; Paiva, Alexandre; Duarte, Ana Rita C.; Matias, AnaDeep eutectic solvents have been recently reported as an interesting alternative to improve the therapeutic efficacy of conventional drugs, hence called therapeutic deep eutectic solvents (THEDES). The main objective of this work was to evaluate the potential of limonene (LIM) based THEDES as new possible systems for cancer treatment. LIM is known to have antitumor activity, however it is highly toxic and cell ...
Valorization of white wine grape pomace through application of subcritical wate...
Pedras, Bruno; Salema-Oom, Madalena; Sá-Nogueira, Isabel Sá-Nogueira; Simões, Pedro; Paiva, Alexandre; Barreiros, SusanaWhite wine grape pomace (WWGP) was treated with subcritical water in a semi-continuous reactor, at 170, 190 and 210 °C. Assays at 210 °C led to highest recovery of carbohydrates (85% of total amount of carbohydrates of WWGP) and phenolic compounds (2.6 g/100 gWWGP). Moreover, 48% of initial lignin was solubilized. The amount of carbohydrates recovered increased sharply in the initial stages of the process, due ...
Natural deep eutectic solvents from choline chloride and betaine - physicochemi...
Aroso, Ivo Manuel Ascensão; Paiva, Alexandre; Reis, R. L.; Duarte, Ana Rita C.The preparation of natural deep eutectic solvents (NADESs) from cheap and readily available raw materials is reported. In this work, we have considered mixtures of choline chloride (CC) or betaine (Bet) with 3 sugar molecules (glucose (Glu), xylose (Xyl) and sucrose (Suc)) and 2 carboxylic acids (citric (CA) and tartaric (Tart) acids). The formation of NADESs was investigated by polarized optical microscopy (PO...
How do animals survive extreme temperature amplitudes? The role of Natural Deep...
Gertrudes, Ana; Craveiro, Rita; Eltayari, Zahara; Reis, R. L.; Paiva, Alexandre; Duarte, Ana Rita C.Recent findings have reported the reason why some living beings are able to withstand the huge thermal amplitudes between winter and summer in their natural habitats. They are able to produce metabolites decreasing deeply the crystallization temperature of water, avoiding cell disrupture due to the presence of ice crystals and overcoming osmotic effects. In vitro, the possibility to cool living cells and tissue...