21 documents found, page 1 of 3

Adult-onset autoimmune diabetes: comparative analysis of classical and latent p...

Introduction: Adult-onset autoimmune diabetes (AID) has two different phenotypes: classic type 1 diabetes mellitus (T1DM), with insulin requirement just after diagnosis, and latent autoimmune diabetes in adults (LADA). The purpose of this study is to characterize patients with AID followed on a tertiary centre, comparing classic T1DM and LADA. Methods: We collected data from patients with diabetes and positive ...

Primary adrenal insufficiency in adult population: a Portuguese multicentre stu...

INTRODUCTION: Primary adrenal insufficiency (PAI) is a rare but severe and potentially life-threatening condition. No previous studies have characterized Portuguese patients with PAI. AIMS: To characterize the clinical presentation, diagnostic workup, treatment and follow-up of Portuguese patients with confirmed PAI. METHODS: This multicentre retrospective study examined PAI patients in 12 Portuguese hospitals....

Feocromocitoma: estudo retrospetivo multicêntrico

Objetivo: O feocromocitoma é um tumor raro com origem no tecido cromafim. Para avaliar a epidemiologia característica e abordagem destes tumores, foi efetuado um estudo multicêntrico retrospetivo em doentes com feocromocitoma. Material e métodos: Estudo retrospetivo, desenvolvido em 12 centros, incluiu 176 doentes tratados entre 1986-2011. Efetuado um questionário que incluiu dados epidemiológicos, clínicos, do...

Hipercortisolismo Recorrente: Após Remoção de Adenoma Hipofisário Secretor de A...

A 29 years old patient was sent to our Outpatient Clinic of Endocrinology presenting clinic of hypercortisolism. Laboratorial study: High urinary free cortisol (UFC); serum cortisol - 25 microg/dl (8 am) (5-25) and 20 microg/dL (11pm); ACTH - 20 pg/mL (9-52) (8 am) and 14 pg/mL (11 pm); serum cortisol after dexamethasone suppression test: 14,9 mg/dL; CRH test: elevation of ACTH; Pituitary MRI: microadenoma; abd...

Feocromocitoma: actualizações no diagnóstico e tratamento

Um Caso Clínico de Diabetes - Discutido no "Workshop": Diabetes e Osteoporose

Introdução: A diabetes mellitus tipo 2 constitui actualmente um grave problema de saúde pública, pela sua elevada incidência e prevalência. A evolução do conhecimento científico conduziu à introdução recente de novos fármacos, assim como à revisão das recomendações internacionais para o tratamento da hiperglicémia e dos objectivos terapêuticos a atingir. No dia 13 de Dezembro de 2008, realizou-se no Palace Hote...

Resistência à hormonas tiroideias

A diabetes na quarta idade: a nossa realidade

AIM: To evaluate the impact of the aging of our population in the growing of diabetes prevalence, among patients treated inward at our department. MATERIAL AND METHODS: The clinical files of 242 diabetics older than eighty years, treated between 1999 and 2002 were studied retrospectively. Demographic (sex, age, year of first contact), clinical (causes of admission, co-morbidities, duration of diabetes, previous...

Terapêutica farmacológica da doença de Cushing

The curative treatment of Cushing's disease is surgery, mainly transphenoidal surgery. The cure probability is high and the risks or complications are few. However, pharmacotherapy is necessary while localisation of the secreting tumour is not achieved, when there is persistence of hypercortisolism after surgery, or while waiting for effectiveness of radiotherapy. We review the existing drugs, their characteris...

Polimorfismos do gene CYP2D6 estão associados a uma susceptibilidade para os tu...

Several polymorphisms of drug-metabolizing enzymes have been implicated in the susceptibility to tumor development. The role of the CYP2D6, GSTM1 and GSTT1 genes has been extensively studied, with alleles conferring different metabolic efficiencies and tumor risk. We studied the relationship between the main polymorphisms of these genes and the susceptibility to develop pituitary tumors, by performing a case-co...