15 documents found, page 1 of 2
Endocan as a marker of endotheliitis in COVID-19 patients: modulation by veno-v...
Reina-Couto, M; Alves, D; Silva-Pereira, C; Pereira-Terra, P; Martins, S; Bessa, J; Teixeira-Santos, L; Pinho, D; Morato, M; Dias, CC; Sarmento, A"Background and aims: Endocan has been scarcely explored in COVID-19, especially regarding its modulation by veno-venous extracorporeal membrane oxygenation (VV-ECMO), hypertension or previous renin-angiotensin-aldosterone system (RAAS) inhibitors treatment. We compared endocan and other endotheliitis markers in hospitalized COVID-19 patients and assessed their modulation by VV-ECMO, hypertension and previous R...
Tixagevimab-cilgavimab (AZD7442) for the treatment of patients hospitalized wit...
Hites, M; Lapique, EL; Massonnaud, CR; Belhadi, D; Jamard, S; Goehringer, F; Danion, F; Reignier, J; de Castro, N; Garot, D; Lacombe, K; Tolsma, V
Hospital Context Determinants of Variability in Healthcare-Associated Infection...
Malheiro, R; Gomes, AA; Fernandes, C; Fareleira, A; Lebre, A; Pascoalinho, D; Gonçalves-Pereira, J; Paiva, JA; Sá-Machado, RHealthcare-associated infections (HAIs) represent a major challenge in patient safety that affects services disproportionally. This paper aimed to assess how the HAI prevalence varies between hospital services and what contextual characteristics may explain such variance. A cross-sectional study was conducted on adult patients in Portuguese hospitals, using data from the European point prevalence survey of HAI ...
Hospital context in surgical site infection following colorectal surgery: a mul...
Malheiro, R; Peleteiro, B; Silva, G; Lebre, A; Paiva, JA; Correia, S"Background Surgical site infections (SSIs) are associated with poor health outcomes. Their incidence is highest after colorectal surgery, with little improvement in recent years. The role of hospital characteristics is undetermined. Aim To investigate whether SSI incidence after colorectal surgery varies between hospitals, and whether such variance may be explained by hospital characteristics. Methods Data wer...
Creatinine Clearance in Acute Brain Injury: A Comparison of Methods
Monteiro, E; Pereira, MF; Barroso, I; Dias, CC; Czosnyka, M; Paiva, JA; Dias, CBackgroundCurrently, the measurement of glomerular filtration rate is very complex and costly, so its daily evaluation is performed using endogenous markers, of which creatinine is the most frequently used. It allows the estimation of glomerular filtration rate by means of its clearance or by formulas based on its serum and urine concentration. Augmented renal clearance (ARC) is frequent among critically ill pa...
Behavioral Components and Context of Antimicrobial Prescription in a Tertiary H...
Almeida-Costa, APM; Paiva, JA; Almeida, AJS; Barbosa, E; Correia, SConsumption of antimicrobials is an important driver of antimicrobial resistance. There is limited knowledge of the key determinants of antimicrobial prescribing behavior in hospitals. An understanding of these determinants is required for the successful design, adoption, and implementation of quality improvement interventions in Antimicrobial Stewardship Programs (ASP). This study aimed to describe the main fa...
Evaluation of urinary cysteinyl leukotrienes as biomarkers of severity and puta...
Reina-Couto, M; Roboredo-Madeira, M; Pereira-Terra, P; Silva-Pereira, C; Martins, S; Teixeira-Santos, L; Pinho, D; Dias, A; Cordeiro, G; Dias, CCBackground Cysteinyl leukotrienes (CysLT) are potent inflammation-promoting mediators, but remain scarcely explored in COVID-19. We evaluated urinary CysLT (U-CysLT) relationship with disease severity and their usefulness for prognostication in hospitalized COVID-19 patients. The impact on U-CysLT of veno-venous extracorporeal membrane oxygenation (VV-ECMO) and of comorbidities such as hypertension and obesity ...
Surveillance of surgical site infection after colorectal surgery: comprehensive...
Malheiro, RM; Peleteiro, B; Silva, G; Lebre, A; Paiva, JA; Correia, SObjective:The incidence of surgical site infection (SSI) is highest after colorectal surgery. We assessed the impact of risk factors for SSI using the population attributable fraction (PAF). Design:Retrospective cohort study. Setting:Portuguese hospitals performing regular surveillance. Patients:We identified patients who underwent colorectal procedures in hospitals that reported colorectal surgeries every year...
Increase of Antimicrobial Consumption in a Tertiary Care Hospital during the Fi...
Castro-Lopes, A; Correia, S; Leal, C; Resende, I; Soares, P; Azevedo, A; Paiva, JABackground: The COVID-19 pandemic poses novel challenges in antimicrobial consumption metrics and stewardship strategies. COVID-19 patients became the major cause of hospital admission during the first wave of the pandemic, often leading to an antimicrobial prescription upon admission or treatment for superinfections. The aim of this study was to understand how antimicrobial consumption was impacted at the begi...
Serum creatinine trajectories in real-world hospitalized patients: clinical con...
Laszczyńska, O; Severo, M; Mascarenhas, J; Paiva, JA; Azevedo, AFluctuations in serum creatinine (SCr) during hospitalization may provide additional prognostic value beyond baseline renal function. This study aimed to identify groups of patients with distinct creatinine trajectories over hospital stay and assess them in terms of clinical characteristics and short-term mortality. This retrospective study included 35 853 unique adult admissions to a tertiary referral center b...