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The Importance of Design in the Development of a Portable and Modular Iot-Based...

Seabra, D; Santos, P; Paiva, JS; Alves, JL; Ramos, A; Cardoso, MJ; Guimarães, JT

The integration of human factors engineering methods within the medical device design and development process has been highlighted by international standards organizations. Such methods are contributing to the development of safer medical devices, more suitable to users' needs. Errors during device operation might hamper effective patient diagnosis and treatment, or eventually lead to injury or death. Thus, the...


Forecasting COVID-19 Severity by Intelligent Optical Fingerprinting of Blood Sa...

Faria, SP; Carpinteiro, C; Pinto, V; Rodrigues, SM; Alves, J; Marques, F; Lourenço, M; Santos, PH; Ramos, A; Cardoso, MJ; Guimarães, JT; Rocha, S

Forecasting COVID-19 disease severity is key to supporting clinical decision making and assisting resource allocation, particularly in intensive care units (ICUs). Here, we investigated the utility of time- and frequency-related features of the backscattered signal of serum patient samples to predict COVID-19 disease severity immediately after diagnosis. ICU admission was the primary outcome used to define dise...


Author Correction: iLoF: An intelligent Lab on Fiber Approach for Human Cancer ...

Paiva, JS; Jorge, PAS; Ribeiro, RSR; Balmaña, M; Campos, D; Mereiter, S; Jin, C; Karlsson, NG; Sampaio, P; Reis, CA; Cunha, JPS

An amendment to this paper has been published and can be accessed via a link at the top of the paper.


iLoF: An intelligent Lab on Fiber Approach for Human Cancer Single-Cell Type Id...

Paiva, JS; Jorge, PAS; Ribeiro, RSR; Balmaña, M; Campos, D; Mereiter, S; Jin, C; Karlsson, NG; Sampaio, P; Reis, CA; Cunha, JPS

With the advent of personalized medicine, there is a movement to develop “smaller” and “smarter” microdevices that are able to distinguish similar cancer subtypes. Tumor cells display major differences when compared to their natural counterparts, due to alterations in fundamental cellular processes such as glycosylation. Glycans are involved in tumor cell biology and they have been considered to be suitable can...


Optical fiber-based sensing method for nanoparticle detection through supervise...

Paiva, JS; Jorge, PAS; Ribeiro, RSR; Sampaio, P; Rosa, CC; Cunha, JPS

Background: In view of the growing importance of nanotechnologies, the detection/identification of nanoparticles type has been considered of utmost importance. Although the characterization of synthetic/organic nanoparticles is currently considered a priority (eg, drug delivery devices, nanotextiles, theranostic nanoparticles), there are many examples of “naturally” generated nanostructures - for example, extra...


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