32 documents found, page 1 of 4
Antileishmanial Acetylene Fatty Acid and Acetogenins from Seeds of Porcelia mac...
Brito,Ivanildo A.; Oliveira,Emerson A.; Chaves,Mariana H.; Thevenard,Fernanda; Rodrigues-Oliveira,André F.; Barbosa-Reis,Gustavo; Sartorelli,PatriciaIn the present work five acetylene derivatives (1-5), including three unknowns (1, 3 and 4), were isolated from seeds of Porcelia macrocarpa (Annonaceae). The structures of isolated compounds were determined as docos-13-yn-21-enoic acid (1), 3-hydroxy-4-methylene-2-(eicos-11’-yn-19’-enyl)but-2-enolide (2), 3-hydroxy-4-methylene-2-(octadec-9’-yn-17’-enyl)but-2-enolide (3), 3-hydroxy-4-methylene-2-(hexadec-7’-yn-...
Electrochemical Preparation and Evaluation of Cytotoxic Activity of Methoxyl-ox...
Silva,Flavia T. da; Gomes,Kaio S.; Machado,Fabricio C.; Loureiro,Leticia L.; Travassos,Luiz R.; Martins,Tereza S.; Lago,João Henrique G.Electrochemical procedures have emerged as a powerful tool for the synthesis of complex organic molecules including transformation of natural products. In this study, the electrosynthesis of biseugenol in MeOH afforded one new oxidized derivative, which was characterized as methoxyl-oxo-biseugenol (MOB) by nuclear magnetic resonance (NMR) and electrospray ionization-high resolution mass spectrometry (ESI-HRMS) ...
Dereplication of Aporphine Alkaloids by UHPLC-HR-ESI-MS/MS and NMR from Dugueti...
Dantas,Erick P.; Monteiro,Jackson; Medeiros,Lívia S. de; Romanelli,Maiara M.; Amaral,Maiara; Tempone,Andre G.; Lago,João Henrique G.; Soares,Marisi G.Although the genus Duguetia is well known for producing alkaloids as chemical constituents, there are no reports of alkaloids identified in the species D. lanceolata. Thus, aiming to identify the chemical composition of this species, the dereplication of alkaloidic phase was performed by use of ultra-high performance liquid chromatography high resolution electrospray ionization tandem mass spectrometry (UHPLC-H...
Antileishmanial activity and immunomodulatory effect of secosubamolide, a butan...
Costa-Silva,Thais A. da; Conserva,Geanne A. Alves; Galisteo Jr,Andrés J.; Tempone,Andre G.; Lago,João Henrique G.Abstract Background: Visceral leishmaniasis is a complex neglected tropical disease caused by Leishmania donovani complex. Its current treatment reveals strong limitations, especially high toxicity. In this context, natural products are important sources of new drug alternatives for VL therapy. Therefore, the antileishmanial and immunomodulatory activity of compounds isolated from Nectandra oppositifolia (Laura...
ISOLATION OF ANTIFUNGAL QUINOID DERIVATIVES FROM LEAVES OF Pentacalia desiderab...
Gomes,Kaio de S.; Tamayose,Cinthia I.; Ferreira,Marcelo José P.; Murakami,Cynthia; Young,Maria Claudia M.; Antar,Guilherme M.; Camilo,Fernanda F.In the present work, leaves of Pentacalia desiderabilis (Asteraceae) were subjected to extraction using aqueous 1-butyl-3-methylimidazolium bromide (BMImBr) in the microwave assisted extraction (MAE). The obtained extract was partitioned using CH2Cl2 and antifungal activity against Cladosporium cladosporioides and C. sphaerospermum of the organic phase was evaluated. Sequentially, this material was subjected to...
A Comparative Study on Chemical Composition, Antileishmanial and Cytotoxic Acti...
Oliveira,Emerson A.; Martins,Euder G. A.; Soares,Marisi G.; PChagas-aula,Daniela A.; Passero,Luiz F. D.; Sartorelli,Patricia; Baldim,João L.Meliaceae representatives are economically important in several aspects including the production of highly prized woods (mahogany, cedar, etc.), constituents for cosmetics, and insecticides. The present study aimed to verify the chemical composition as well as leishmanicidal and cytotoxic potential of essential oils from leaves of two different populations of Guarea macrophylla collected at cities of São Paulo ...
ISOLATION OF CYTOTOXIC NEOLIGNANS FROM Saururus cernuus L. (SAURURACEAE) USING ...
Brito,Juliana R.; Camilo,Fernanda F.; Figueiredo,Carlos R.; Azevedo,Ricardo A.; Romoff,Paulete; Buturi,Fátima O. S.; Fávero,Oriana A.In the present work, dried leaves of Saururus cernuus (Saururaceae) were subjected to extraction using an ionic liquid (1-butyl-3-methylimidazolium bromide - BMImBr) in the microwave assisted extraction (MAE). The obtained extract was partitioned using n-hexane and cytotoxicity activity of this organic phase against murine melanoma cell line (B16F10-Nex2) was evaluated in vitro. Since this extract displayed act...
Application of an Ionic Liquid in the Microwave Assisted Extraction of Cytotoxi...
Morais,Thiago R.; Coutinho,Ana Paula R.; Camilo,Fernanda F.; Martins,Tereza S.; Sartorelli,Patricia; Massaoka,Mariana H.; Figueiredo,Carlos R.This work reports the application of an ionic liquid (1-butyl-3-methylimidazolium bromide, BMImBr) in the microwave assisted extraction (MAE) of metabolites from fruits of Schinus terebinthifolius. Dried fruits were individually extracted using BMImBr:H2O 1:1, v/v (experiment 1) and pure H2O (experiment 2) by MAE (10 min at 60 ºC). After partition using EtOAc, the yield to experiment 1 was about 23% while to ex...
Exudates used as medicine by the "caboclos river-dwellers" of the Unini River, ...
Lago,João Henrique G.; Tezoto,Jaqueline; Yazbek,Priscila B.; Cassas,Fernando; Santos,Juliana de F.L.; Rodrigues,ElianaAbstract Although the use of exudates in traditional medicine has been commonly observed during ethnopharmacological surveys, few records have been made concerning the scientific merits of these products. The aim of this study was to document ethnopharmacological data and to classify exudates used as medicine by the "caboclos" river-dwellers from the Unini River of Amazonas, Brazil, on chemical analyses basis. ...
A new flavonoid derivative from leaves of Oxandra Sessiliflora R. E. Fries
Sousa,Elcilene A. de; Silva,Armenio A. C. A. da; Cavalheiro,Alberto J.; Lago,João Henrique G.; Chaves,Mariana H.The ethyl acetate (EtOAc) phase obtained from the partition of the ethanol (EtOH) extract from leaves of O. sessiliflora R. E. Fries (Annonaceae) was subjected to several chromatographic steps, including high efficiency liquid chromatography (HPLC), to afford the flavonoids: quercetin-3-O-α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranoside (1), unprecedented in the literature, kaempferol-3-O-α-L-rhamnopyranosyl-(1→4)...