3 documents found, page 1 of 1
Peptidylprolyl isomerase C (Ppic) regulates invariant Natural Killer T cell (iN...
Paiva, Ricardo S.; Ramos, Camila V.; Azenha, Sara R.; Alves, Carolina; Basto, Afonso; Graca, Luis; Martins, Vera C.Peptidyl-prolyl cis-trans isomerase C (Ppic) is expressed in several bone marrow (BM) hematopoietic progenitors and in T-cell precursors. Since the expression profile of Ppic in the hematoimmune system was suggestive that it could play a role in hematopoiesis and/or T lymphocyte differentiation, we sought to test that hypothesis in vivo. Specifically, we generated a Ppic-deficient mouse model by targeting the e...
Peptidylprolyl isomerase C (Ppic) regulates invariant Natural Killer T cell (iN...
Paiva, Ricardo S.; Ramos, Camila V.; Azenha, Sara R.; Alves, Carolina; Basto, Afonso P.; Graça, Luís; Martins, Vera C.Peptidyl-prolyl cis-trans isomerase C (Ppic) is expressed in several bone marrow (BM) hematopoietic progenitors and in T-cell precursors. Since the expression profile of Ppic in the hematoimmune system was suggestive that it could play a role in hematopoiesis and/or T lymphocyte differentiation, we sought to test that hypothesis in vivo. Specifically, we generated a Ppic-deficient mouse model by targeting the e...
Recent thymic emigrants are the preferential precursors of regulatory T cells d...
Paiva, Ricardo S.; Lino, Andreia C.; Bergman, Marie-Louise; Caramalho, Íris; Sousa, Ana E.; Zelenay, Santiago; Demengeot, JocelyneMost Forkhead box P3(+) (Foxp3(+)) CD4 regulatory T cell (Treg) precursors are newly formed thymocytes that acquire Foxp3 expression on antigen encounter in the thymus. Differentiation of Treg, however, can also occur in the periphery. What limits this second layer of self- and nonself-reactive Treg production in physiological conditions remains to be understood. In this work, we tested the hypothesis that, sim...