Publisher Copyright: © 2024 The Author(s); Background: The time frame for mechanical thrombectomy (MT) in acute ischemic stroke (AIS) is enlarging. Guidelines recommend MT until 6 h of symptom onset in M2 segment occlusions (grade IIB). In practice, it is frequently performed later. Aims: To assess the functional prognosis of AIS patients subjected to M2 segment's MT beyond 6 h, compared to standard interventio...