77 documents found, page 1 of 8
Immunoblot evaluation of rubella humoral immunity in Portuguese women with nega...
Chasqueira, Maria-Jesus; Costa, Sara; Paixão, Margarida; Albuquerque, Margarida; Rego, Maria José Sousa; Paixão, PauloDespite its low incidence in Europe, rubella's immune status is still routinely assessed using commercial immunoassays. However, some discrepancies have been observed between these tests and the Immunoblot. The main objective of this study is to evaluate, by a commercial immunoblot, the immune status of a female population that had previously presented negative, low-positive, or equivocal rubella IgG with a com...
Diagnóstico da Doença Renal Crónica em Adultos em Portugal
Malheiro, Jorge; Birne, Rita; Biscaia, André; Almeida, Edgar; Nobre, João; Capela, Nuno; Azinheira, Jorge; Nunes Oliveira, Jorge; Lebre, LuísPublisher Copyright: Copyright © Ordem dos Médicos 2025.; Chronic kidney disease represents a significant public health issue, affecting approximately 9.8% of the adult population in Portugal. Despite this figure, early diagnosis of this disease in high-risk groups remains limited. Although only two parameters are essential for its diagnosis – estimated glomerular filtration rate (eGFR) and albuminuria – in Por...
SARS-CoV-2 Infection in Children
Martins, Catarina; Ângelo-Dias, Miguel; Chasqueira, Maria-Jesus; Brito, Maria João; Silva, Tiago Milheiro; Matos, Maria Vitória; Lopes, Maria TeresaChildren with COVID-19 typically experience milder symptoms and lower hospitalization rates, though severe cases do occur. Understanding age-related immune responses is crucial for future preparedness. We characterized immune response dynamics to SARS-CoV-2 in 145 samples from 119 pediatric patients (<18 years) with confirmed infection, assessed at four distinct time points: <14 days, 14 days-3 months, 3-6 mont...
Diagnosis of Chronic Kidney Disease in Adults in Portugal: Practical Recommenda...
Malheiro, Jorge; Birne, Rita; Biscaia, André; Almeida, Edgar; Nobre, João; Capela, Nuno; Azinheira, Jorge; Nunes Oliveira, Jorge; Lebre, LuísA doença renal crónica representa um problema de saúde pública significativo, afetando cerca de 9,8% da população adulta em Portugal. Pese embora este número, o diagnóstico precoce desta doença nos grupos de alto risco é reduzido. Apesar de serem apenas dois os parâmetros cruciais para o seu diagnóstico – a taxa de filtração glomerular estimada (TFGe) e a albuminúria – em Portugal, mais de 50% dos doentes em es...
Bioavailability and Bioequivalence: Meaning, Origin and Scientific, Pharmaceuti...
Paixão, Paulo; Silva, Nuno Elvas; Lobato, Maria do Rosário; Guimarães Morais, José A.This article intends to focus on the meaning, origin and use (scientific, pharmaceutical and regulatory) of the concepts underlying the following related terms: Bioavailability, Biogalenics and Bioequivalence. The aim is to provide a historical perspective on the evolution of these concepts in terms of improving their definitions, the underlying science and their acceptance and use by the scientific community, ...
Probe-based metagenomic pathogen detection: advancing laboratory capacity for c...
Ferreira, Rita; Coelho, Luís; Santos, João Dourado; Sobral, Daniel; Isidro, Joana; Mixão, Verónica; Pinto, Miguel; Nunes, Alexandra; Borrego, Maria JoséProbe-based pathogen enrichment, followed by NGS, is a promising tool for complex diagnosis, overcoming traditional challenges of shotgun metagenomics, namely small microbial/human genetic material ratio and demanding computational resources. Here, we assessed the combined detection performance of two Illumina probe-based panels, the Respiratory and the Urinary Pathogen ID panels (RPIP and UPIP), using 99 clini...
Probe-based metagenomic pathogen detection
Ferreira, Rita; Coelho, Luís; Santos, João Dourado; Sobral, Daniel; Isidro, Joana; Mixão, Verónica; Pinto, Miguel; Nunes, Alexandra; Borrego, Maria JoséPublisher Copyright: Copyright © 2025 Ferreira, Coelho, Santos, Sobral, Isidro, Mixão, Pinto, Nunes, Borrego, Lopo, Oleastro, Sousa, Palminha, Veríssimo, Gargaté, Guiomar, Cordeiro, Macedo, Bajanca-Lavado, Paixão, Duarte, Vieira, Borges and Gomes.; Probe-based pathogen enrichment, followed by NGS, is a promising tool for complex diagnosis, overcoming traditional challenges of shotgun metagenomics, namely small ...
Correction to the Article "Diagnosis of Chronic Kidney Disease in Adults in Por...
Malheiro, Jorge; Birne , Rita; Biscaia , André; Almeida , Edgar; Nobre, João; Capela, Nuno; Azinheira, Jorge; Nunes Oliveira, Jorge; Lebre, LuísFollowing publication of the original article, the authors identified an error in the content. The corrected text is presented in the PDF. The original article has also been corrected. Chronic kidney disease represents a significant public health issue, affecting approximately 9.8% of the adult population in Portugal. Despite this figure, early diagnosis of this disease in high-risk groups remains limited. Alth...
Corrigendum to “Consensus recommendation for prenatal, neonatal and postnatal m...
Leruez-Ville, Marianne; Chatzakis, Christos; Lilleri, Daniele; Blazquez-Gamero, Daniel; Alarcon, Ana; Bourgon, Nicolas; Foulon, Ina; Fourgeaud, JacquesFunding Information: MLV reports receiving support for attending meetings by BioM\u00E9rieux and Altona outside the submitted work. MLV reports payment made to her institution for presentation/lecture by Diasorin, Abbott Molecular and Roche Diagnostic outside the submitted work. DBG received Grant from the Spanish Ministry of Science and Innovation. ISCIII and Fondos FEDER (EU) outside the submitted work and re...
Antimicrobial Resistance Genes in Legionella from Artificial Water Systems
Pereira, Bernardo Beirão; Marrafa, Mário; Cruz, Carolina; Rodrigues, Lúcia; Nunes, Filipa; Monteiro, Silvia; Santos, Ricardo; Carneiro, Rui NevesBackground: Legionella species are the causative agent of Legionnaires’ disease and, as ubiquitous waterborne bacteria, are prone to antimicrobial resistance gene (ARG) acquisition and dissemination due to the antimicrobial contamination of natural environments. Given the potential health risks associated with ARGs, it is crucial to assess their presence in the Legionella population. Methods: The ARGs lpeAB and...