9 documents found, page 1 of 1
Optimistic and pessimistic cognitive judgement bias modulates the stress respon...
Espigares, Felipe; Alvarado, M. Victoria; Abad-Tortosa, Diana; Varela, Susana A. M.; Sobral, Daniel; Faísca, Pedro; Paixão, Tiago; Oliveira, RuiCognitive judgement bias in decision-making under ambiguity occurs both in animals and humans, with some individuals interpreting ambiguous stimulus as positive (optimism) and others as negative (pessimism). We hypothesize that judgement bias is a personality trait and that individuals with a pessimistic bias would be more reactive to stressors and therefore more susceptible to stress-related diseases than opti...
Evolution of resistance and disease tolerance mechanisms to oral bacterial infe...
Paulo, Tânia F.; Akyaw, Priscilla A.; Paixão, Tiago; Sucena, ÉlioPathogens exert strong selection on hosts that evolve and deploy different defensive strategies, namely minimizing pathogen exposure (avoidance), directly promoting pathogen elimination (resistance) and/or managing the deleterious effects of illness (disease tolerance). However, how the host response partitions across these processes has not been directly tested in a single host–pathogen system, let alone in th...
Targeting circulating labile heme as a defense strategy against malaria
Ramos, Susana; Jeney, Viktoria; Figueiredo, Ana; Paixão, Tiago; Sambo, Maria Rosário; Quinhentos, Vatúsia; Martins, Rui; Gouveia, ZéliaSevere presentations of malaria emerge as Plasmodium (P.) spp. parasites invade and lyse red blood cells (RBC), producing extracellular hemoglobin (HB), from which labile heme is released. Here, we tested whether scavenging of extracellular HB and/or labile heme, by haptoglobin (HP) and/or hemopexin (HPX), respectively, counter the pathogenesis of severe presentations of malaria. We found that circulating labil...
The Rare DRB1*04:08-DQ8 Haplotype is the Main HLA Class II Genetic Driver and D...
Caramalho, Iris; Matoso, Paula; Ligeiro, Dário; Paixão, Tiago; Sobral, Daniel; Fitas, Ana Laura; Limbert, Catarina; Demengeot, JocelyneIntroduction: Early-onset Type 1 diabetes (EOT1D) is considered a disease subtype with distinctive immunological and clinical features. While both Human Leukocyte Antigen (HLA) and non-HLA variants contribute to age at T1D diagnosis, detailed analyses of EOT1D-specific genetic determinants are still lacking. This study scrutinized the involvement of the HLA class II locus in EOT1D genetic control. Methods: We c...
Phenotypic architecture of sociality and its associated genetic polymorphisms i...
Gonçalves, Claúdia; Kareklas, Kyriacos; Teles, Magda C; Varela, Susana.A.M.; Costa, João; Leite, Ricardo B.; Paixão, Tiago; Oliveira, Rui FilipeSociality relies on motivational and cognitive components that may have evolved independently, or may have been linked by phenotypic correlations driven by a shared selective pressure for increased social competence. Furthermore, these components may be domain-specific or of general-domain across social and non-social contexts. Here, we used zebrafish to test if the motivational and cognitive components of soci...
Fabry-Perot Interferometer Based on Suspended Core Fiber for Detection of Gaseo...
Paixão, Tiago; Nunes, Ana Sofia; Bierlich, Jörg; Kobelke, Jens; Ferreira, Marta S.An optical fiber tip sensor based on a Fabry-Perot interferometer is proposed for the detection of ethanol in the gas phase. The sensor is fabricated by fusion splicing one end of the suspended core fiber to a single mode fiber, whereas the other end is kept open to enable the interaction between the light propagating in the suspended core and the ethanol gas molecules. The sensor was tested with different perc...
Role of omega-6 fatty acid metabolism in cardiac surgery postoperative bleeding...
Velho, Tiago R.; Ferreira, Ricardo; Willmann, Katharina; Pedroso, Dora; Paixão, Tiago; Pereira, Rafael Maniés; Junqueira, Nádia; Carvalho Guerra, NunoCardiac surgery is frequently associated with significant postoperative bleeding. Platelet-dysfunction is the main cardiopulmonary bypass (CPB)-induced hemostatic defect. Not only the number of platelets decreases, but also the remaining are functionally impaired. Although lipid metabolism is crucial for platelet function, little is known regarding platelet metabolic changes associated with CPB-dysfunction. Our...
Modelling, fabrication and characterization of long period gratings inscribed b...
Vieira, Joana; Paixão, Tiago; Antunes, Paulo; Facão, Margarida; Rocha, Ana M.In this paper, we present a method to fabricate long period gratings in standard telecommunications single mode fibers (SSMF), using a femtosecond laser system. A numerical model based on the coupled mode theory was developed and implemented with the aim to guide and improve the inscribing technique. This model takes in consideration the specifications of the inscription technique. Using this model, we have ana...
Liquid level gauge based in plastic optical fiber
Antunes, Paulo; Dias, João; Paixão, Tiago; Mesquita, Esequiel; Varum, Humberto; André, PauloThis work reports de development and testing of a low cost plastic optical fiber liquid level sensor for operation within highly flammable or other hazardous environments, such in oil piping or fuel tanks. The sensor consists on a vertical fiber, with engraved grooves, that will be sequentially fulfill when the liquid rises, resulting in an increase of the transmitted optical power. A variation of 2.60% in the ...