4 documents found, page 1 of 1
Early alveolar macrophage response and IL-1R-dependent T cell priming determine...
Lovey, Arianne; Verma, Sheetal; Kaipilyawar, Vaishnavi; Ribeiro-Rodrigues, Rodrigo; Husain, Seema; Palaci, Moises; Dietze, Reynaldo; Ma, ShuyiFunding Information: The work was funded by the National Institute of Allergy and Infectious Diseases, National Institutes of Health grants U19AI111276 and U01AI065663 to R.R.R., R.D., J.J.E. and P.S., and NIAID training grant T32AI125185 to A.L. The study sponsors were not involved in the study design, in the collection, analysis, and interpretation of data; in the writing of the manuscript; or in the decision...
Host determinants of infectiousness in smear-positive patients with pulmonary t...
Acuña-Villaorduña, Carlos; Ayakaka, Irene; Schmidt-Castellani, Luiz Guilherme; Mumbowa, Francis; Marques-Rodrigues, Patricia; Gaeddert, MaryBackground Epidemiologic data suggests that only a minority of tuberculosis (TB) patients are infectious. Cough aerosol sampling is a novel quantitative method to measure TB infectiousness. Methods We analyzed data from three studies conducted in Uganda and Brazil over a 13-year period. We included sputum acid fast bacilli (AFB) and culture positive pulmonary TB patients and used a cough aerosol sampling system...
Transmission phenotype of mycobacterium tuberculosis strains is mechanistically...
Verma, Sheetal; Bhatt, Kamlesh; Lovey, Arianne; Ribeiro-Rodrigues, Rodrigo; Durbin, Joan; Jones-López, Edward C.; Palaci, Moises; Vinhas, Solange A.In a study of household contacts (HHC), households were categorized into High (HT) and Low (LT) transmission groups based on the proportion of HHC with a positive tuberculin skin test. The Mycobacterium tuberculosis (Mtb) strains from HT and LT index cases of the households were designated Mtb-HT and Mtb-LT, respectively. We found that C3HeB/FeJ mice infected with Mtb-LT strains exhibited significantly higher b...
Cough-Aerosol cultures of Mycobacterium tuberculosis in the prediction of outco...
Acuña-Villaorduña, Carlos; Schmidt-Castellani, Luiz Guilherme; Marques-Rodrigues, Patricia; White, Laura F.; Hadad, David Jamil; Gaeddert, MaryBackground Mycobacterium tuberculosis cultures of cough-generated aerosols from patients with pulmonary tuberculosis (TB) are a quantitative method to measure infectiousness and to predict secondary outcomes in exposed contacts. However, their reproducibility has not been established. Objective To evaluate the predictive value of colony-forming units (CFU) of M.Tuberculosis in cough aerosols on secondary infect...