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Presynaptic vesicle protein SEPTIN5 regulates the degradation of APP C-Terminal...
Marttinen, Mikael; Ferreira, Catarina B.; Paldanius, Kaisa M. A.; Takalo, Mari; Natunen, Teemu; Mäkinen, Petra; Leppänen, Luukas; Leinonen, VilleAlzheimer's disease (AD) is a neurodegenerative disease characterized by aberrant amyloid-β (Aβ) and hyperphosphorylated tau aggregation. We have previously investigated the involvement of SEPTIN family members in AD-related cellular processes and discovered a role for SEPTIN8 in the sorting and accumulation of β-secretase. Here, we elucidated the potential role of SEPTIN5, an interaction partner of SEPTIN8, in...
Data: 2020
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Origem: Repositório da Universidade de Lisboa