2 documents found, page 1 of 1
Entry inhibitors and Carbosilane dendrimers are potent inhibitors of cell-assoc...
Diniz, A. R.; Briz, V.; Borrego, P.; Palladino, C.; Rodés, C.; De la Mata, F. J.; Gómez, R.; Muñoz-Fernández, M. A.; Taveira, N."Pre-exposure prophylaxis with topical microbicides formulated with antiviral agents can prevent HIV-1 acquisition. The ideal microbicide should prevent both cell-free and cell-associated HIV-1 and HIV-2 infections in the vaginal or rectum mucosa. So far, few candidate microbicides have been tested against HIV-2. Previously, we have shown that anionic carbosilane dendrimers 2G-S16 (sulphonate), G2-NF16 (naphthy...
Evaluation of an in-house molecular HIV-1 test to assess mother-to-child HIV-1 ...
Martin, F.; Palladino, C.; Mateus, R.; Clemente, S.; Gomes, P.; Taveira, N."Mother-to-child-transmission (MTCT) rate has decreased sharply in recent years in most of the sub-Saharan Africa, however 220,000 children acquired HIV-1 in 2014. PCR detection of proviral DNA is the most sensitive method for early infant diagnosis (EID) of HIV-1 infection. Commercial kits are available but they have poor sensitivity with divergent non-B subtypes and high costs (≈30€ per test) which limit thei...