4 documents found, page 1 of 1
ZIKV Strains Elicit Different Inflammatory and Anti-Viral Responses in Microgli...
Oliveira, Fernanda Bellaniza Caminha de; Freire, Vanessa Paola Alves Sampaio de Sá; Coelho, Sharton Vinicius Antunes; Meuren, Lana MonteiroIn recent years, the Zika Virus (ZIKV) has caused pandemic outbreaks associated with a high rate of congenital ZIKV syndrome (CZS). Although all strains associated with worldwide outbreaks derive from the Asian lineage, the reasons for their enhanced spread and severity are not fully understood. In this study, we conducted a comparative analysis of miRNAs (miRNA-155/146a/124) and their cellular targets (SOCS1/3...
Alpha‐1‐antitrypsin : a possible host protective factor against Covid‐19
Loyola, Mariana Braccialli de; Reis, Thaís Tereza Aguiar dos; Oliveira, Guilherme Xavier Lyra Malcher de; Palmeira, Julys da FonsecaUnderstanding Covid‐19 pathophysiology is crucial for a better understanding of the disease and development of more effective treatments. Alpha‐1‐antitrypsin (A1AT) is a constitutive tissue protector with antiviral and anti‐inflammatory properties. A1AT inhibits SARS‐CoV‐2 infection and two of the most important proteases in the pathophysiology of Covid‐19: the transmembrane serine protease 2 (TMPRSS2) and the ...
Phosphatidylserine inside out : a possible underlying mechanism in the infammat...
Argañaraz, Gustavo Adolfo; Palmeira, Julys da Fonseca; Argañaraz, Enrique RobertoThe rapid ability of SARS-CoV-2 to spread among humans, along with the clinical complications of coronavirus disease 2019—COVID-19, have represented a significant challenge to the health management systems worldwide. The acute inflammation and coagulation abnormalities appear as the main causes for thousands of deaths worldwide. The intense inflammatory response could be involved with the formation of thrombi. ...
ACE2/ADAM17/TMPRSS2 interplay may be the main risk factor for COVID-19
Zipeto, Donato; Palmeira, Julys da Fonseca; Argañaraz, Gustavo Adolfo; Argañaraz, Enrique RobertoThe Coronavirus Disease 2019 (COVID-19) has already caused hundreds of thousands of deaths worldwide in a few months. Cardiovascular disease, hypertension, diabetes and chronic lung disease have been identified as the main COVID-19 comorbidities. Moreover, despite similar infection rates between men and women, the most severe course of the disease is higher in elderly and co-morbid male patients. Therefore, the...