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Detection of circulating tumor cells in renal cancer : the impact of no-touch s...
Palmela Leitão, Tito
Clinical validation of a size-based microfluidic device for circulating tumor c...
Palmela Leitão, Tito; Corredeira, Patrícia; Kucharczak, Sandra; Rodrigues, Margarida; Piairo, Paulina; Rodrigues, Carolina; Alves, PatríciaRenal cell carcinoma (RCC) presents as metastatic disease in one third of cases. Research on circulating tumor cells (CTCs) and liquid biopsies is improving the understanding of RCC biology and metastases formation. However, a standardized, sensitive, specific, and cost-effective CTC detection technique is lacking. The use of platforms solely relying on epithelial markers is inappropriate in RCC due to the freq...
Circulating tumor cell detection methods in renal cell carcinoma : a systematic...
Palmela Leitão, Tito; Miranda, Miguel; Polido, Joana; Morais, João; Corredeira, Patrícia; Alves, Patrícia; Ribeiro-de-Oliveira, TiagoCirculating tumor cells (CTCs) have a potential role as the missing renal cell carcinoma (RCC) biomarker. However, the available evidence is limited, and detection methods lack standardization, hindering clinical use. We performed a systematic review on CTC enrichment and detection methods, and its role as a biomarker in RCC. Full-text screening identified 54 studies. Reviewed studies showed wide heterogeneity,...
A prospective randomized trial comparing the Vienna nomogram and a ten-core pro...
Palmela Leitão, Tito; Alfarelos, Joana; Rodrigues, Teresa; Pereira E Silva, Ricardo; Garcia, Rodrigo; Martinho, David; Sandul, Anatoliy; Mendonça, TiagoWe performed a prospective randomized study of men undergoing prostate biopsy randomized to a Vienna nomogram protocol (group A) or a 10-core protocol (group B). The results suggest that the use of the Vienna nomogram does not significantly increase the overall cancer detection rate compared with a 10-core biopsy scheme. Further prospective randomized studies, with adequate sample sizes, are needed to definitiv...