5 documents found, page 1 of 1
Impact of the Secretome of Human Mesenchymal Stem Cells on Brain Structure and ...
Teixeira, Fábio G.; Carvalho, Miguel M.; Panchalingam, Krishna M.; Rodrigues, Ana J.; Mendes-Pinheiro, Bárbara; Anjo, Sandra I.; Manadas, BrunoResearch in the last decade strongly suggests that mesenchymal stem cell (MSC)-mediated therapeutic benefits are mainly due to their secretome, which has been proposed as a possible therapeutic tool for the treatment of Parkinson's disease (PD). Indeed, it has been shown that the MSC secretome increases neurogenesis and cell survival, and has numerous neuroprotective actions under different conditions. Addition...
Modulation of the Mesenchymal Stem Cell Secretome Using Computer-Controlled Bio...
Teixeira, Fábio G.; Panchalingam, Krishna M.; Assunção-Silva, Rita; Serra, Sofia C.; Mendes-Pinheiro, Bárbara; Patrício, Patrícia; Jung, SunghoonIn recent years it has been shown that the therapeutic benefits of human mesenchymal stem/stromal cells (hMSCs) in the Central Nervous System (CNS) are mainly attributed to their secretome. The implementation of computer-controlled suspension bioreactors has shown to be a viable route for the expansion of these cells to large numbers. As hMSCs actively respond to their culture environment, there is the hypothes...
Modulation of the mesenchymal stem cell secretome using computer-controlled bio...
Teixeira, Fábio Gabriel Rodrigues; Panchalingam, Krishna M.; Silva, Rita Catarina Assunção Ribeiro; Serra, Sofia CravinoIn recent years it has been shown that the therapeutic benefits of human mesenchymal stem/ stromal cells (hMSCs) in the Central Nervous System (CNS) are mainly attributed to their secretome. The implementation of computer-controlled suspension bioreactors has shown to be a viable route for the expansion of these cells to large numbers. As hMSCs actively respond to their culture environment, there is the hypothe...
Do hypoxia/normoxia culturing conditions change the neuroregulatory profile of ...
Teixeira, Fábio Gabriel Rodrigues; Panchalingam, Krishna M.; Anjo, Sandra Isabel; Manadas, Bruno; Pereira, Ricardo Nuno Correia; Sousa, NunoIntroduction: The use of human umbilical cord Wharton Jelly-derived mesenchymal stem cells (hWJ-MSCs) has been considered a new potential source for future safe applications in regenerative medicine. Indeed, the application of hWJ-MSCs into different animal models of disease, including those from the central nervous system, has shown remarkable therapeutic benefits mostly associated with their secretome. Conven...
Secretome of Mesenchymal Progenitors from the Umbilical Cord Acts as Modulator ...
Teixeira, Fábio Gabriel Rodrigues; Carvalho, Miguel Moreira; Carvalho, Andreia Alexandra Neves; Panchalingam, Krishna M.; Behie, Leo A.; Pinto, LuísaIt was recently shown that the conditioned media (CM) of Human Umbilical Cord Perivascular Cells (HUCPVCs), a mesenchymal progenitor population residing within the Wharton Jelly of the umbilical cord, was able to modulate in vitro the survival and viability of different neuronal and glial cells populations. In the present work, we aimed to assess if the secretome of HUCPVCs is able to 1) induce the differentiat...