18 documents found, page 1 of 2
GVHD-derived plasma as a priming strategy of mesenchymal stem cells
Carvalho, Amandda Évelin Silva; Rodrigues, Leane Perim; Schiavinato, Josiane Lilian; Alborghetti, Marcos Rodrigo; Bettarello, GustavoBackground: Mesenchymal stem cell (MSC) therapy is an important alternative for GVHD treatment, but a third of patients fail to respond to such therapy. Therefore, strategies to enhance the immunosuppressive potential of MSCs constitute an active area of investigation. Here, we proposed an innovative priming strategy based on the plasma obtained from GVHD patients and tested whether this approach could enhance ...
Focused screening reveals functional effects of microRNAs differentially expres...
Panepucci, Rodrigo Alexandre
High-content screen in human pluripotent cells identifies miRNA-regulated pathw...
Panepucci, Rodrigo Alexandre
A high-content screening approach to identify microRNAs against head and neck c...
Panepucci, Rodrigo Alexandre
High-content screen in human pluripotent cells identifies miRNA-regulated pathw...
de Souza Lima, Ildercílio Mota; Schiavinato, Josiane Lilian Dos Santos; Paulino Leite, Sarah Blima; Sastre, DanutaBackground: By post-transcriptionally regulating multiple target transcripts, microRNAs (miRNAs or miR) play important biological functions. H1 embryonic stem cells (hESCs) and NTera-2 embryonal carcinoma cells (ECCs) are two of the most widely used human pluripotent model cell lines, sharing several characteristics, including the expression of miRNAs associated to the pluripotent state or with differentiation....
HOX genes: potential candidates for the progression of laryngeal squamous cell ...
de Barros e Lima Bueno, Rafaela; Ram�o, Anelisa; Pinheiro, Daniel Guariz [UNESP]; Alves, Cleidson Padua; Kannen, Vinicius; Jungbluth, Achim AMade available in DSpace on 2018-12-11T17:23:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-11-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Laryngeal squamous cell carcinoma (LSCC) is a very aggressive cancer, considered to be a subtype of the head and neck squamous cell carcinoma (HNSCC). Despite significant ...
TGF-beta/atRA-induced Tregs express a selected set of microRNAs involved in the...
Panepucci, Rodrigo Alexandre
LL-37 boosts immunosuppressive function of placenta-derived mesenchymal stromal...
Bravo, Martha Oliveira; Sangiorgi, Bruno Braga; Schiavinato, Josiane Lilian dos Santos; Carvalho, Juliana Lott; Covas, Dimas TadeuBackground: Although promising for graft-versus-host disease (GvHD) treatment, MSC therapy still faces important challenges. For instance, increasing MSC migratory capacity as well as potentializing immune response suppression are of interest. For GvHD management, preventing opportunistic infections is also a valuable strategy, since immunocompromised patients are easy targets for infections. LL-37 is a host de...
DSP30 enhances the immunosuppressive properties of mesenchymal stromal cells an...
Panepucci, Rodrigo Alexandre
Potential roles of microRNA-29a in the molecular pathophysiology of T-cell acut...
Panepucci, Rodrigo Alexandre