23 documents found, page 1 of 3
Serum and renal tissue markers of nephropathy in rats under immunosuppressive t...
Sereno, J.; Parada, B.; Rodrigues-Santos, P.; Lopes, P.; Carvalho, E.; Vala, Helena; Teixeira-Lemos, E.; Alves, R.; Figueiredo, A.; Mota, A.Cyclosporin (CsA) has been progressively replaced by other drugs with putatively fever side effects, including nephrotoxicity and hypertension. Sirolimus (SRL) is one of the main options for management of kidney transplant patients in the post-CsA era. It shows identical efficacy with apparently less cardiorenal side effects than CsA. However, doubts remain concerning the mechanisms of putative renoprotection b...
Cardiac antiapoptotic and proproliferative effect of recombinant human erythrop...
Teixeira, M.; Rodrigues-Santos, P.; Garrido, P.; Costa, E; Parada, B.; Sereno, J.; Alves, R.; Belo, L; Teixeira, F.; Santos-Silva, A.; Reis, F.Objective: Recombinant human erythropoietin (rhEPO) therapy under circumstances of moderate chronic renal failure (CRF), with yet lower kidney and heart lesion, may have a protective cardiac effect beyond the correction of anemia, whose mechanism deserves better elucidation, namely by clarifying the impact on gene expression profile of markers of apoptosis, inflammation, proliferation, angiogenesis, and lesion/...
Cardiac antiapoptotic and proproliferative effect of recombinant human erythrop...
Teixeira, M.; Rodrigues-Santos, P.; Garrido, P.; Costa, E.; Parada, B.; Sereno, J.; Alves, R.; Belo, L.; Teixeira, F.; Santos-Silva, A.; Reis, F.Objective: Recombinant human erythropoietin (rhEPO) therapy under circumstances of moderate chronic renal failure (CRF), with yet lower kidney and heart lesion, may have a protective cardiac effect beyond the correction of anemia, whose mechanism deserves better elucidation, namely by clarifying the impact on gene expression profile of markers of apoptosis, inflammation, proliferation, angiogenesis, and lesion/...
Sitagliptin delays progression of renal lesions in a rodent model of type 2 dia...
Cristina, M.; Vala, Helena; Oliveira, J.; Fernandes, R.; Mascarenhas-Melo, F.; Parada, B.; Pinto, R.; Teixeira, F.; Reis, F.; Teixeira de Lemos, E.
Sirolimus ameliorates cyclosporin-induced nephrotoxicity in a rat model – focus...
Sereno, José; Romão, A. M.; Teixeira, M.; Parada, B.; Mega, C.; Vala, Helena; Lemos, E. T.; Teixeira, F.; Reis, F.
Sitagliptin delays progression of renal lesions in a rodent model of type 2 dia...
Mega, C.; Vala, Helena; Oliveira, J.; Fernandes, R.; Mascarenhas-Melo, F.; Parada, B.; Pinto, R.; Teixeira, F.; Reis, F.; Lemos, E. T.
Sitagliptin treatment delays the progression of pancreatic and renal lesions an...
Mega, C.; Vala, Helena; Oliveira, J.; Fernandes, R.; Mascarenhas-Melo, F.; Parada, B.; Pinto, R.; Teixeira, F.; Reis, F.; Lemos, E. T.
Progression of renal disease in the Zucker Diabetic Fatty rat, an experimental ...
Mega, C.; Vala, Helena; Oliveira, J.; Fernandes, R.; Mascarenhas-Melo, F.; Parada, B.; Pinto, R.; Teixeira, F.; Reis, F.; Teixeira de Lemos, E.
Pancreatic lesions and metabolic aggravation are prevented by low doses of sita...
Mega, C.; Vala, Helena; Oliveira, J.; Fernandes, R.; Mascarenhas-Melo, F.; Parada, B.; Pinto, R.; Teixeira, F.; Teixeira de Lemos, E.; Reis, F.Introduction: The management of type 2 diabetes is designed to reduce disease-related complications and improve long-term outcomes. Inhibition of dipeptidyl peptidase-4 (DPP-4) activity by sitagliptin has been shown to improve glycaemic control in patients with type 2 diabetes Mellitus (T2DM) by prolonging the actions of incretin hormones, but the real impact of low-dose sitagliptin treatment on cardiometabolic...
Renal structure modification in an animal model of type 2 diabetes with aging: ...
Mega, C.; Vala, Helena; Oliveira, J.; Fernandes, R.; Mascarenhas-Melo, F.; Parada, B.; Pinto, R.; Teixeira, F.; Teixeira de Lemos, E.; Reis, F.Background and aims: The Zucker Diabetic Fatty (ZDF-fa/fa) rat is one of the most used models for the study of type 2 diabetes (T2DM). Characterization of renal morphology in this model may provide useful insights into the mechanism of diabetic nephropathy progression. The purpose of the present study was to determine renal morphology, identify and characterize renal dysfunction complications such as hydronephr...