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Adenosine A2A Receptors in the Rat Prelimbic Medial Prefrontal Cortex Control D...
Leffa, Douglas T; Pandolfo, Pablo; Gonçalves, Nélio; Machado, Nuno J.; de Souza, Carolina M; Real, Joana I.; Silva, Antonio C.; Silva, Henrique B.Adenosine A2A receptors (A2ARs) were recently described to control synaptic plasticity and network activity in the prefrontal cortex (PFC). We now probed the role of these PFC A2AR by evaluating the behavioral performance (locomotor activity, anxiety-related behavior, cost-benefit decision making and working memory) of rats upon downregulation of A2AR selectively in the prelimbic medial PFC (PLmPFC) via viral s...
Date: 2018
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Origin: Estudo Geral - Universidade de Coimbra