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Trends of Transmitted and Acquired Drug Resistance in Europe From 1981 to 2019

Miranda, Mafalda N.S.; Pingarilho, Marta; Pimentel, Victor; Martins, Maria do Rosário O.; Kaiser, Rolf; Seguin-Devaux, Carole; Paredes, Roger

Funding Information: We want to thank Frank Tang, Bin Lin, Mike Cohen and the rest of the Google speech team for their insightful discussions and inputs. Publisher Copyright: Copyright © 2022 Miranda, Pingarilho, Pimentel, Martins, Kaiser, Seguin-Devaux, Paredes, Zazzi, Incardona and Abecasis.; Background: The increased use of antiretroviral therapy (ART) has decreased mortality and morbidity of HIV-1 infected ...


Remdesivir for the treatment of patients hospitalized with COVID-19 receiving s...

Beckerman, Rachel; Gori, Andrea; Jeyakumar, Sushanth; Malin, Jakob J.; Paredes, Roger; Povoa, Pedro; Smith, Nathaniel J.; Teixeira-Pinto, Armando

This network meta-analysis (NMA) assessed the efficacy of remdesivir in hospitalized patients with COVID-19 requiring supplemental oxygen. Randomized controlled trials of hospitalized patients with COVID-19, where patients were receiving supplemental oxygen at baseline and at least one arm received treatment with remdesivir, were identified. Outcomes included mortality, recovery, and no longer requiring supplem...


Determinants of HIV-1 late presentation in patients followed in europe

Miranda, Mafalda N.S.; Pingarilho, Marta; Pimentel, Victor; Martins, Maria Do Rosário O.; Vandamme, Anne Mieke; Bobkova, Marina; Böhm, Michael

Funding Information: This study was financed by FCT through the following projects: GHTM-UID/04413/2020, INTEGRIV (PTDC/SAU-INF/31990/2017) and the scholarship PD/BD/135714/2018 and Gilead Ge?nese HIVLatePresenters. Funding Information: Funding: This study was financed by FCT through the following projects: GHTM-UID/04413/2020, INTEGRIV (PTDC/SAU-INF/31990/2017) and the scholarship PD/BD/135714/2018 and Gilead ...


Earlier initiation of antiretroviral treatment coincides with an initial contro...

Vinken, Lore; Katrien, Fransen,; Cuypers, Lize; Alexiev, Ivailo; Balotta, Claudia; Laurent, Debaisieux,; Carole, Seguin-Devaux,; Sergio Garcìa, Ribas,

Human immunodeficiency virus type 1 (HIV-1) non-B subtype infections occurred in Belgium since the 1980s, mainly amongst migrants and heterosexuals, whereas subtype B predominated in men-having-sex-with-men (MSM). In the last decade, the diagnosis of F1 sub-subtype in particular has increased substantially, which prompted us to perform a detailed reconstruction of its epidemiological history. To this purpose, t...


HIV-1 Infection in Cyprus, the Eastern Mediterranean European Frontier

Pineda-Peña, Andrea Clemencia; Theys, Kristof; Stylianou, Dora C.; Demetriades, Ioannis; Puchhammer, Elisabeth; Vandamme, Anne Mieke; Aleksiev, Ivailo

Since HIV-1 treatment is increasingly considered an effective preventionstrategy, it is important to study local HIV-1 epidemics to formulate tailored preventionpolicies. The prevalence of HIV-1 in Cyprus was historically low until 2005. To investigatethe shift in epidemiological trends, we studied the transmission dynamics of HIV-1 in Cyprususing a densely sampled Cypriot HIV-1 transmission cohort that include...


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